Safety and Preliminary Efficacy of Intranasal Insulin for Cognitive Impairment in Parkinson Disease and Multiple System Atrophy 1.0

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Study No	Pharmacy	excluded	IversusP	Pre-Post	Age	Gender	Etnicity	Smoking	Height (in)	Weight	BMI	Disease	Disease Duration	SBP	DBP	HR	Walk-Duration	Walk-NoSteps	AverStride (in)	MOCA	Glucose	SBP	DBP	HR	BMI 2	Walk-Duration 2	Walk-NoSteps 2	AverStrid (in) 2	Gait Speed 2	HnH	PGI-I	BDI	MOCA 2	F#words	A#words	S#words	FAS	Pre-Post	Glucose 2	MOCA 3	Walk-Duration 3	Walk-NoSteps 3	AverStrid (in) 3	Gait Speed 3	HnH 2	PGI-I 2	BDI 2	F#words 2	A#words 2
1	n/a	excluded/screen failure																																				Post
2	1-PD		0	Pre	79	1	w	0	69	176	26.02	PD	3	154	88	66	5.81	9	16	26	84	148	82	62	26.02	4.76	7	21	1.050420168	2.5	3	17	27	16	7	8	31	Post	73	24	5.45	9	16	0.917431193	2.5	3	13	6	4
3	2-PD		1	Pre	64	1	w	0	76.5	184	22.1	PD	9	129	83	70	3.72	7	21	30	89	129	83	70	22.1	3.9	7	21	1.282051282	2.5	3	3	30	15	16	15	46	Post	83	29	4.08	7	21	1.225490196	2.5	3	3	15	17
4	3-PD		0	Pre	53	2	w	0	67	155	24.3	PD	5	113	69	70	3.84	8	18	28	98	113	69	70	24.3	4.4	8	18	1.136363636	2.5	3	15	29	11	11	12	34	Post	98	30	4.55	8	18	1.098901099	2.5	3	13	11	8
5	4-PD		1	Pre	71	1	a	0	68	157	23.9	PD	17	114	74	62	3.37	7	21	26	83	114	64	72	23.9	3.19	6	24	1.567398119	2.5	3	6	28	16	12	9	37	Post	72	28	3.73	7	21	1.340482574	2.5	3	3	16	16
6	5-PD		0	Pre	56	2	w	0	60	140	27.3	PD	5	112	75	80	4.67	8	18	28	86	112	73	78	27.3	4.65	8	18	1.075268817	2.5	3	14	30	11	12	11	34	Post	112	29	5.13	8	18	0.974658869	2.5	3	20	10	11
7	6-PD		0	Pre	66	2	w	0	63	123	21.8	PD	7	139	83	66	4.11	6	24	25	106	139	83	66	21.8	4.23	6	24	1.182033097	2	3	2	27	15	10	10	35	Post	77	30	4.08	6	24	1.225490196	2.5	3	0	10	7
8	7-PD		1	Pre	66	1	w	0	61.1	197	27.5	PD	6	114	69	73	3.66	8	18	28	100	114	69	73	27.5	3.66	8	18	1.366120219	2	3	4	27	10	8	16	34	Post	100	28	3.7	6	24	1.351351351	1	3	2	12	12
9	8-PD		1	Pre	64	2	w	0	65	115	18.8	PD	4	128	70	72	3.68	6	24	28	88	128	70	72	18.8	4.4	7	21	1.136363636	2.5	3	6	30	12	8	14	34	Post	79	28	3.4	7	21	1.470588235	1	3	4	13	9
10	9-PD		0	Pre	56	1	w	0	75	275	34.4	PD	3	132	84	108	3.78	6	24	29	103	135	81	102	34.4	3.7	7	21	1.351351351	2	3	17	25	8	8	13	29	Post	97	29	3.6	7	21	1.388888889	2.5	3	20	10	9
11	10-PD		1	Pre	65	2	w	0	68	125	19	PD	4	147	98	90	6.03	11	13	28	79	124	80	75	19	4.89	9	16	1.022494888	4	3	20	29	14	15	13	42	Post	77	30	6.16	10	14	0.811688312	2.5	4	26	11	10
12	11-PD		1	Pre	60	1	w	0	77	229	28.2	PD	2	111	67	59	3.01	5.5	26	28	90	111	67	59	28.2	2.83	5	29	1.766784452	2.5	3	6	28	9	10	11	30	Post	95	27		6	24	mv	1.5	3	5	8	8
13	12-PD		0	Pre	63	1	w	0	68	255	38.8	PD	8	138	87	67	5.11	7	21	24	81	138	87	67	38.8	4.38	6	24	1.141552511	3	3	16	23	9	11	14	34	Post	63	27	4.64	8	18	1.077586207	2	2	11	15	12
14	13-PD	Excluded Adverse event	1	Pre
15	14-PD		1	Pre	66	1	w	0	68	185	28.1	PD	10	mv	mv	mv	4.2	8	18	27	95	mv	mv	mv	28.1	4.43	8	18	1.128668172	2.5	3	7	28	16	9	18	43	Post	85	27	4.25	8	18	1.176470588	2.5	3	11	18	12
16	1-MSA		1	Pre	50	1	w	0	MV	mv	mv	MSA	2	104	68	59	3.11	5	29	27	97	104	68	59	mv	2.75	5	29	1.818181818	2.5	3	11	30	14	13	17	44	Post	94	27	2.99	5	29	1.672240803	2.5	3	12	16	12

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