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We thank J.Y. Wei, D. Kaliton and J. Mietus for valuable discussions and assistance. This work was supported in part by grants AG-14100, AG-08812, AG-00294, and AG-10829 from the National Institute of Aging and grant MH-54081 from the National Institute of Mental Health. We are also grateful for partial support from the American Federation for Aging Research, the G. Harold and Leila Y. Mathers Charitable Foundation, and from the National Aeronautics and Space Administration.