CiPA ECG Validation Study 1.0.0
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| STUDYID | USUBJID | TRTSEQP | TRTP | TRTSEQA | TRTA | PARAM | PARAMCD | APERIOD | APERIODC | AVISIT | AVISITN | ATPT | ATPTN | ATPTREF | ARDTM | AARDTM | ARRLT | NRRLT | RRLTU | ADTM | ADT | ATM | ADY | AVISDY | APERDAY | EGREPNUM | AVAL | AVALC | EGSTRESU | DTYPE | ABLFL | AEGBLFL | BASE | CHG | BASETYPE | ACOMPFL | COMP | COMPBASE | COMPCHG | CCOMPCHG | COMPTYPE | ECGPCFL | EGSEQ | EGLEAD | EGREFID | CRIT1 | CRIT1FL | CRIT2 | CRIT2FL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -1.055 | -1 | HOURS | 2017-03-27 05:56:42 | 2017-03-27 | 05:56:42 | 1 | 1 | 1 | 1 | 73 | 73 | bpm | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 2 | GLOBAL | D9D41F54-A34C-40A4-BC44-20C74EFC644D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -1.04138888888889 | -1 | HOURS | 2017-03-27 05:57:31 | 2017-03-27 | 05:57:31 | 1 | 1 | 1 | 2 | 66 | 66 | bpm | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 3 | GLOBAL | A0192DFC-3630-478E-81F9-EE9C07F6EC8E | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -1.02111111111111 | -1 | HOURS | 2017-03-27 05:58:44 | 2017-03-27 | 05:58:44 | 1 | 1 | 1 | 3 | 65 | 65 | bpm | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 4 | GLOBAL | FA1B1A68-1B94-4895-A678-E2B940D7B1BF | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | NA | -1 | HOURS | 1 | 1 | 1 | NA | 68 | 68 | bpm | AVERAGE | Y | NA | NA | Day 1 predose | 56.9259259259259 | NA | NA | NA | Placebo group | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -1.055 | -1 | HOURS | 2017-03-27 05:56:42 | 2017-03-27 | 05:56:42 | 1 | 1 | 1 | 1 | 221 | 221 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 2 | VCGMAG | D9D41F54-A34C-40A4-BC44-20C74EFC644D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -1.04138888888889 | -1 | HOURS | 2017-03-27 05:57:31 | 2017-03-27 | 05:57:31 | 1 | 1 | 1 | 2 | 228 | 228 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 3 | VCGMAG | A0192DFC-3630-478E-81F9-EE9C07F6EC8E | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -1.02111111111111 | -1 | HOURS | 2017-03-27 05:58:44 | 2017-03-27 | 05:58:44 | 1 | 1 | 1 | 3 | 228 | 228 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 4 | VCGMAG | FA1B1A68-1B94-4895-A678-E2B940D7B1BF | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | NA | -1 | HOURS | 1 | 1 | 1 | NA | 225.666666666667 | 225.666666666667 | ms | AVERAGE | Y | NA | NA | Day 1 predose | 235.185185185185 | NA | NA | NA | Placebo group | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -1.055 | -1 | HOURS | 2017-03-27 05:56:42 | 2017-03-27 | 05:56:42 | 1 | 1 | 1 | 1 | 247.181280640245 | 247.181280640245 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 2 | VCGMAG | D9D41F54-A34C-40A4-BC44-20C74EFC644D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -1.04138888888889 | -1 | HOURS | 2017-03-27 05:57:31 | 2017-03-27 | 05:57:31 | 1 | 1 | 1 | 2 | 240.146267477098 | 240.146267477098 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 3 | VCGMAG | A0192DFC-3630-478E-81F9-EE9C07F6EC8E | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -1.02111111111111 | -1 | HOURS | 2017-03-27 05:58:44 | 2017-03-27 | 05:58:44 | 1 | 1 | 1 | 3 | 237.935158408136 | 237.935158408136 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 4 | VCGMAG | FA1B1A68-1B94-4895-A678-E2B940D7B1BF | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | NA | -1 | HOURS | 1 | 1 | 1 | NA | 241.754235508493 | 241.754235508493 | ms | AVERAGE | Y | NA | NA | Day 1 predose | 228.202034138228 | NA | NA | NA | Placebo group | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -1.055 | -1 | HOURS | 2017-03-27 05:56:42 | 2017-03-27 | 05:56:42 | 1 | 1 | 1 | 1 | 184 | 184 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 2 | GLOBAL | D9D41F54-A34C-40A4-BC44-20C74EFC644D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -1.04138888888889 | -1 | HOURS | 2017-03-27 05:57:31 | 2017-03-27 | 05:57:31 | 1 | 1 | 1 | 2 | 184 | 184 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 3 | GLOBAL | A0192DFC-3630-478E-81F9-EE9C07F6EC8E | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -1.02111111111111 | -1 | HOURS | 2017-03-27 05:58:44 | 2017-03-27 | 05:58:44 | 1 | 1 | 1 | 3 | 186 | 186 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 4 | GLOBAL | FA1B1A68-1B94-4895-A678-E2B940D7B1BF | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | NA | -1 | HOURS | 1 | 1 | 1 | NA | 184.666666666667 | 184.666666666667 | ms | AVERAGE | Y | NA | NA | Day 1 predose | 162 | NA | NA | NA | Placebo group | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -1.055 | -1 | HOURS | 2017-03-27 05:56:42 | 2017-03-27 | 05:56:42 | 1 | 1 | 1 | 1 | 81 | 81 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 2 | VCGMAG | D9D41F54-A34C-40A4-BC44-20C74EFC644D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -1.04138888888889 | -1 | HOURS | 2017-03-27 05:57:31 | 2017-03-27 | 05:57:31 | 1 | 1 | 1 | 2 | 80 | 80 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 3 | VCGMAG | A0192DFC-3630-478E-81F9-EE9C07F6EC8E | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -1.02111111111111 | -1 | HOURS | 2017-03-27 05:58:44 | 2017-03-27 | 05:58:44 | 1 | 1 | 1 | 3 | 80 | 80 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 4 | VCGMAG | FA1B1A68-1B94-4895-A678-E2B940D7B1BF | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | NA | -1 | HOURS | 1 | 1 | 1 | NA | 80.3333333333333 | 80.3333333333333 | ms | AVERAGE | Y | NA | NA | Day 1 predose | 85.6666666666667 | NA | NA | NA | Placebo group | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -1.055 | -1 | HOURS | 2017-03-27 05:56:42 | 2017-03-27 | 05:56:42 | 1 | 1 | 1 | 1 | 363 | 363 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 2 | VCGMAG | D9D41F54-A34C-40A4-BC44-20C74EFC644D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -1.04138888888889 | -1 | HOURS | 2017-03-27 05:57:31 | 2017-03-27 | 05:57:31 | 1 | 1 | 1 | 2 | 368 | 368 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 3 | VCGMAG | A0192DFC-3630-478E-81F9-EE9C07F6EC8E | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -1.02111111111111 | -1 | HOURS | 2017-03-27 05:58:44 | 2017-03-27 | 05:58:44 | 1 | 1 | 1 | 3 | 368 | 368 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 4 | VCGMAG | FA1B1A68-1B94-4895-A678-E2B940D7B1BF | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | NA | -1 | HOURS | 1 | 1 | 1 | NA | 366.333333333333 | 366.333333333333 | ms | AVERAGE | Y | NA | NA | Day 1 predose | 393.148148148148 | NA | NA | NA | Placebo group | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -1.055 | -1 | HOURS | 2017-03-27 05:56:42 | 2017-03-27 | 05:56:42 | 1 | 1 | 1 | 1 | 387.124852408285 | 387.124852408285 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 2 | VCGMAG | D9D41F54-A34C-40A4-BC44-20C74EFC644D | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -1.04138888888889 | -1 | HOURS | 2017-03-27 05:57:31 | 2017-03-27 | 05:57:31 | 1 | 1 | 1 | 2 | 379.142450638465 | 379.142450638465 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 3 | VCGMAG | A0192DFC-3630-478E-81F9-EE9C07F6EC8E | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -1.02111111111111 | -1 | HOURS | 2017-03-27 05:58:44 | 2017-03-27 | 05:58:44 | 1 | 1 | 1 | 3 | 377.132244063066 | 377.132244063066 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 4 | VCGMAG | FA1B1A68-1B94-4895-A678-E2B940D7B1BF | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | NA | -1 | HOURS | 1 | 1 | 1 | NA | 381.133182369939 | 381.133182369939 | ms | AVERAGE | Y | NA | NA | Day 1 predose | 385.889698674804 | NA | NA | NA | Placebo group | NA | VCGMAG | QTCF>=450 | N | QTCF>=500 | N | ||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -1.055 | -1 | HOURS | 2017-03-27 05:56:42 | 2017-03-27 | 05:56:42 | 1 | 1 | 1 | 1 | 824.454545454545 | 824.454545454545 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 2 | GLOBAL | D9D41F54-A34C-40A4-BC44-20C74EFC644D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -1.04138888888889 | -1 | HOURS | 2017-03-27 05:57:31 | 2017-03-27 | 05:57:31 | 1 | 1 | 1 | 2 | 914.4 | 914.4 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 3 | GLOBAL | A0192DFC-3630-478E-81F9-EE9C07F6EC8E | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -1.02111111111111 | -1 | HOURS | 2017-03-27 05:58:44 | 2017-03-27 | 05:58:44 | 1 | 1 | 1 | 3 | 929.1 | 929.1 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 4 | GLOBAL | FA1B1A68-1B94-4895-A678-E2B940D7B1BF | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | NA | -1 | HOURS | 1 | 1 | 1 | NA | 889.318181818182 | 889.318181818182 | ms | AVERAGE | Y | NA | NA | Day 1 predose | 1061.58274544386 | NA | NA | NA | Placebo group | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -1.055 | -1 | HOURS | 2017-03-27 05:56:42 | 2017-03-27 | 05:56:42 | 1 | 1 | 1 | 1 | 61 | 61 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 2 | VCGMAG | D9D41F54-A34C-40A4-BC44-20C74EFC644D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -1.04138888888889 | -1 | HOURS | 2017-03-27 05:57:31 | 2017-03-27 | 05:57:31 | 1 | 1 | 1 | 2 | 60 | 60 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 3 | VCGMAG | A0192DFC-3630-478E-81F9-EE9C07F6EC8E | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -1.02111111111111 | -1 | HOURS | 2017-03-27 05:58:44 | 2017-03-27 | 05:58:44 | 1 | 1 | 1 | 3 | 60 | 60 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 4 | VCGMAG | FA1B1A68-1B94-4895-A678-E2B940D7B1BF | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | -1 hrs | 1 | Morning fasted dose | 2017-03-27 07:00:00 | NA | -1 | HOURS | 1 | 1 | 1 | NA | 60.3333333333333 | 60.3333333333333 | ms | AVERAGE | Y | NA | NA | Day 1 predose | 72.2962962962963 | NA | NA | NA | Placebo group | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.552222222222222 | -0.5 | HOURS | 2017-03-27 06:26:52 | 2017-03-27 | 06:26:52 | 1 | 1 | 1 | 1 | 68 | 68 | bpm | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 45 | GLOBAL | 7248F3BC-9EFF-49B2-99B0-E3B5168615B8 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.544722222222222 | -0.5 | HOURS | 2017-03-27 06:27:19 | 2017-03-27 | 06:27:19 | 1 | 1 | 1 | 2 | 69 | 69 | bpm | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 47 | GLOBAL | 044CD94A-F0C5-412F-AE85-7D843BA687D8 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.533333333333333 | -0.5 | HOURS | 2017-03-27 06:28:00 | 2017-03-27 | 06:28:00 | 1 | 1 | 1 | 3 | 69 | 69 | bpm | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 49 | GLOBAL | 5A6FC621-2F40-4274-9B8E-BBB602976302 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | NA | -0.5 | HOURS | 1 | 1 | 1 | NA | 68.6666666666667 | 68.6666666666667 | bpm | AVERAGE | Y | NA | NA | Day 1 predose | 60.3333333333333 | NA | NA | NA | Placebo group | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.552222222222222 | -0.5 | HOURS | 2017-03-27 06:26:52 | 2017-03-27 | 06:26:52 | 1 | 1 | 1 | 1 | 226 | 226 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 45 | VCGMAG | 7248F3BC-9EFF-49B2-99B0-E3B5168615B8 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.544722222222222 | -0.5 | HOURS | 2017-03-27 06:27:19 | 2017-03-27 | 06:27:19 | 1 | 1 | 1 | 2 | 225 | 225 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 47 | VCGMAG | 044CD94A-F0C5-412F-AE85-7D843BA687D8 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.533333333333333 | -0.5 | HOURS | 2017-03-27 06:28:00 | 2017-03-27 | 06:28:00 | 1 | 1 | 1 | 3 | 227 | 227 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 49 | VCGMAG | 5A6FC621-2F40-4274-9B8E-BBB602976302 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | NA | -0.5 | HOURS | 1 | 1 | 1 | NA | 226 | 226 | ms | AVERAGE | Y | NA | NA | Day 1 predose | 229.533333333333 | NA | NA | NA | Placebo group | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.552222222222222 | -0.5 | HOURS | 2017-03-27 06:26:52 | 2017-03-27 | 06:26:52 | 1 | 1 | 1 | 1 | 243.963799514196 | 243.963799514196 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 45 | VCGMAG | 7248F3BC-9EFF-49B2-99B0-E3B5168615B8 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.544722222222222 | -0.5 | HOURS | 2017-03-27 06:27:19 | 2017-03-27 | 06:27:19 | 1 | 1 | 1 | 2 | 244.793877705765 | 244.793877705765 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 47 | VCGMAG | 044CD94A-F0C5-412F-AE85-7D843BA687D8 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.533333333333333 | -0.5 | HOURS | 2017-03-27 06:28:00 | 2017-03-27 | 06:28:00 | 1 | 1 | 1 | 3 | 245.664577251568 | 245.664577251568 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 49 | VCGMAG | 5A6FC621-2F40-4274-9B8E-BBB602976302 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | NA | -0.5 | HOURS | 1 | 1 | 1 | NA | 244.807418157176 | 244.807418157176 | ms | AVERAGE | Y | NA | NA | Day 1 predose | 229.460798822816 | NA | NA | NA | Placebo group | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.552222222222222 | -0.5 | HOURS | 2017-03-27 06:26:52 | 2017-03-27 | 06:26:52 | 1 | 1 | 1 | 1 | 191 | 191 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 45 | GLOBAL | 7248F3BC-9EFF-49B2-99B0-E3B5168615B8 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.544722222222222 | -0.5 | HOURS | 2017-03-27 06:27:19 | 2017-03-27 | 06:27:19 | 1 | 1 | 1 | 2 | 189 | 189 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 47 | GLOBAL | 044CD94A-F0C5-412F-AE85-7D843BA687D8 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.533333333333333 | -0.5 | HOURS | 2017-03-27 06:28:00 | 2017-03-27 | 06:28:00 | 1 | 1 | 1 | 3 | 192 | 192 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 49 | GLOBAL | 5A6FC621-2F40-4274-9B8E-BBB602976302 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | NA | -0.5 | HOURS | 1 | 1 | 1 | NA | 190.666666666667 | 190.666666666667 | ms | AVERAGE | Y | NA | NA | Day 1 predose | 164.9 | NA | NA | NA | Placebo group | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.552222222222222 | -0.5 | HOURS | 2017-03-27 06:26:52 | 2017-03-27 | 06:26:52 | 1 | 1 | 1 | 1 | 78 | 78 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 45 | VCGMAG | 7248F3BC-9EFF-49B2-99B0-E3B5168615B8 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.544722222222222 | -0.5 | HOURS | 2017-03-27 06:27:19 | 2017-03-27 | 06:27:19 | 1 | 1 | 1 | 2 | 78 | 78 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 47 | VCGMAG | 044CD94A-F0C5-412F-AE85-7D843BA687D8 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.533333333333333 | -0.5 | HOURS | 2017-03-27 06:28:00 | 2017-03-27 | 06:28:00 | 1 | 1 | 1 | 3 | 77 | 77 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 49 | VCGMAG | 5A6FC621-2F40-4274-9B8E-BBB602976302 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | NA | -0.5 | HOURS | 1 | 1 | 1 | NA | 77.6666666666667 | 77.6666666666667 | ms | AVERAGE | Y | NA | NA | Day 1 predose | 84.9666666666667 | NA | NA | NA | Placebo group | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.552222222222222 | -0.5 | HOURS | 2017-03-27 06:26:52 | 2017-03-27 | 06:26:52 | 1 | 1 | 1 | 1 | 364 | 364 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 45 | VCGMAG | 7248F3BC-9EFF-49B2-99B0-E3B5168615B8 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.544722222222222 | -0.5 | HOURS | 2017-03-27 06:27:19 | 2017-03-27 | 06:27:19 | 1 | 1 | 1 | 2 | 363 | 363 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 47 | VCGMAG | 044CD94A-F0C5-412F-AE85-7D843BA687D8 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.533333333333333 | -0.5 | HOURS | 2017-03-27 06:28:00 | 2017-03-27 | 06:28:00 | 1 | 1 | 1 | 3 | 362 | 362 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 49 | VCGMAG | 5A6FC621-2F40-4274-9B8E-BBB602976302 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | NA | -0.5 | HOURS | 1 | 1 | 1 | NA | 363 | 363 | ms | AVERAGE | Y | NA | NA | Day 1 predose | 387.666666666667 | NA | NA | NA | Placebo group | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.552222222222222 | -0.5 | HOURS | 2017-03-27 06:26:52 | 2017-03-27 | 06:26:52 | 1 | 1 | 1 | 1 | 380.357149848012 | 380.357149848012 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 45 | VCGMAG | 7248F3BC-9EFF-49B2-99B0-E3B5168615B8 | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.544722222222222 | -0.5 | HOURS | 2017-03-27 06:27:19 | 2017-03-27 | 06:27:19 | 1 | 1 | 1 | 2 | 381.023245573736 | 381.023245573736 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 47 | VCGMAG | 044CD94A-F0C5-412F-AE85-7D843BA687D8 | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.533333333333333 | -0.5 | HOURS | 2017-03-27 06:28:00 | 2017-03-27 | 06:28:00 | 1 | 1 | 1 | 3 | 378.818169951328 | 378.818169951328 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 49 | VCGMAG | 5A6FC621-2F40-4274-9B8E-BBB602976302 | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | NA | -0.5 | HOURS | 1 | 1 | 1 | NA | 380.066188457692 | 380.066188457692 | ms | AVERAGE | Y | NA | NA | Day 1 predose | 387.326558776388 | NA | NA | NA | Placebo group | NA | VCGMAG | QTCF>=450 | N | QTCF>=500 | N | ||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.552222222222222 | -0.5 | HOURS | 2017-03-27 06:26:52 | 2017-03-27 | 06:26:52 | 1 | 1 | 1 | 1 | 876.454545454545 | 876.454545454545 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 45 | GLOBAL | 7248F3BC-9EFF-49B2-99B0-E3B5168615B8 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.544722222222222 | -0.5 | HOURS | 2017-03-27 06:27:19 | 2017-03-27 | 06:27:19 | 1 | 1 | 1 | 2 | 864.7 | 864.7 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 47 | GLOBAL | 044CD94A-F0C5-412F-AE85-7D843BA687D8 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.533333333333333 | -0.5 | HOURS | 2017-03-27 06:28:00 | 2017-03-27 | 06:28:00 | 1 | 1 | 1 | 3 | 872.636363636364 | 872.636363636364 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 49 | GLOBAL | 5A6FC621-2F40-4274-9B8E-BBB602976302 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | NA | -0.5 | HOURS | 1 | 1 | 1 | NA | 871.263636363636 | 871.263636363636 | ms | AVERAGE | Y | NA | NA | Day 1 predose | 1008.1135978836 | NA | NA | NA | Placebo group | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.552222222222222 | -0.5 | HOURS | 2017-03-27 06:26:52 | 2017-03-27 | 06:26:52 | 1 | 1 | 1 | 1 | 60 | 60 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 45 | VCGMAG | 7248F3BC-9EFF-49B2-99B0-E3B5168615B8 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.544722222222222 | -0.5 | HOURS | 2017-03-27 06:27:19 | 2017-03-27 | 06:27:19 | 1 | 1 | 1 | 2 | 60 | 60 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 47 | VCGMAG | 044CD94A-F0C5-412F-AE85-7D843BA687D8 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.533333333333333 | -0.5 | HOURS | 2017-03-27 06:28:00 | 2017-03-27 | 06:28:00 | 1 | 1 | 1 | 3 | 58 | 58 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 49 | VCGMAG | 5A6FC621-2F40-4274-9B8E-BBB602976302 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | -0.5 hrs | 2 | Morning fasted dose | 2017-03-27 07:00:00 | NA | -0.5 | HOURS | 1 | 1 | 1 | NA | 59.3333333333333 | 59.3333333333333 | ms | AVERAGE | Y | NA | NA | Day 1 predose | 73.1666666666667 | NA | NA | NA | Placebo group | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.0755555555555556 | 0 | HOURS | 2017-03-27 06:55:28 | 2017-03-27 | 06:55:28 | 1 | 1 | 1 | 1 | 65 | 65 | bpm | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 116 | GLOBAL | 447ED380-1A06-4AA9-B0A5-504F6AB66863 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.0472222222222222 | 0 | HOURS | 2017-03-27 06:57:10 | 2017-03-27 | 06:57:10 | 1 | 1 | 1 | 2 | 64 | 64 | bpm | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 121 | GLOBAL | 00689D31-8491-4643-B3C8-45241FBBD47C | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.0383333333333333 | 0 | HOURS | 2017-03-27 06:57:42 | 2017-03-27 | 06:57:42 | 1 | 1 | 1 | 3 | 67 | 67 | bpm | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 124 | GLOBAL | F82BCAAB-FD0C-457A-B584-1A25DF594D4F | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 0 | HOURS | 1 | 1 | 1 | NA | 65.3333333333333 | 65.3333333333333 | bpm | AVERAGE | Y | NA | NA | Day 1 predose | 58.0666666666667 | NA | NA | NA | Placebo group | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.0755555555555556 | 0 | HOURS | 2017-03-27 06:55:28 | 2017-03-27 | 06:55:28 | 1 | 1 | 1 | 1 | 233 | 233 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 116 | VCGMAG | 447ED380-1A06-4AA9-B0A5-504F6AB66863 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.0472222222222222 | 0 | HOURS | 2017-03-27 06:57:10 | 2017-03-27 | 06:57:10 | 1 | 1 | 1 | 2 | 232 | 232 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 121 | VCGMAG | 00689D31-8491-4643-B3C8-45241FBBD47C | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.0383333333333333 | 0 | HOURS | 2017-03-27 06:57:42 | 2017-03-27 | 06:57:42 | 1 | 1 | 1 | 3 | 229 | 229 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 124 | VCGMAG | F82BCAAB-FD0C-457A-B584-1A25DF594D4F | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 0 | HOURS | 1 | 1 | 1 | NA | 231.333333333333 | 231.333333333333 | ms | AVERAGE | Y | NA | NA | Day 1 predose | 234.766666666667 | NA | NA | NA | Placebo group | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.0755555555555556 | 0 | HOURS | 2017-03-27 06:55:28 | 2017-03-27 | 06:55:28 | 1 | 1 | 1 | 1 | 244.373972545972 | 244.373972545972 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 116 | VCGMAG | 447ED380-1A06-4AA9-B0A5-504F6AB66863 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.0472222222222222 | 0 | HOURS | 2017-03-27 06:57:10 | 2017-03-27 | 06:57:10 | 1 | 1 | 1 | 2 | 239.983940455375 | 239.983940455375 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 121 | VCGMAG | 00689D31-8491-4643-B3C8-45241FBBD47C | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.0383333333333333 | 0 | HOURS | 2017-03-27 06:57:42 | 2017-03-27 | 06:57:42 | 1 | 1 | 1 | 3 | 243.571709206541 | 243.571709206541 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 124 | VCGMAG | F82BCAAB-FD0C-457A-B584-1A25DF594D4F | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 0 | HOURS | 1 | 1 | 1 | NA | 242.643207402629 | 242.643207402629 | ms | AVERAGE | Y | NA | NA | Day 1 predose | 230.090775400567 | NA | NA | NA | Placebo group | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.0755555555555556 | 0 | HOURS | 2017-03-27 06:55:28 | 2017-03-27 | 06:55:28 | 1 | 1 | 1 | 1 | 186 | 186 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 116 | GLOBAL | 447ED380-1A06-4AA9-B0A5-504F6AB66863 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.0472222222222222 | 0 | HOURS | 2017-03-27 06:57:10 | 2017-03-27 | 06:57:10 | 1 | 1 | 1 | 2 | 188 | 188 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 121 | GLOBAL | 00689D31-8491-4643-B3C8-45241FBBD47C | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.0383333333333333 | 0 | HOURS | 2017-03-27 06:57:42 | 2017-03-27 | 06:57:42 | 1 | 1 | 1 | 3 | 188 | 188 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 124 | GLOBAL | F82BCAAB-FD0C-457A-B584-1A25DF594D4F | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 0 | HOURS | 1 | 1 | 1 | NA | 187.333333333333 | 187.333333333333 | ms | AVERAGE | Y | NA | NA | Day 1 predose | 164.266666666667 | NA | NA | NA | Placebo group | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.0755555555555556 | 0 | HOURS | 2017-03-27 06:55:28 | 2017-03-27 | 06:55:28 | 1 | 1 | 1 | 1 | 78 | 78 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 116 | VCGMAG | 447ED380-1A06-4AA9-B0A5-504F6AB66863 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.0472222222222222 | 0 | HOURS | 2017-03-27 06:57:10 | 2017-03-27 | 06:57:10 | 1 | 1 | 1 | 2 | 78 | 78 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 121 | VCGMAG | 00689D31-8491-4643-B3C8-45241FBBD47C | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.0383333333333333 | 0 | HOURS | 2017-03-27 06:57:42 | 2017-03-27 | 06:57:42 | 1 | 1 | 1 | 3 | 79 | 79 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 124 | VCGMAG | F82BCAAB-FD0C-457A-B584-1A25DF594D4F | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 0 | HOURS | 1 | 1 | 1 | NA | 78.3333333333333 | 78.3333333333333 | ms | AVERAGE | Y | NA | NA | Day 1 predose | 85.0333333333333 | NA | NA | NA | Placebo group | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.0755555555555556 | 0 | HOURS | 2017-03-27 06:55:28 | 2017-03-27 | 06:55:28 | 1 | 1 | 1 | 1 | 372 | 372 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 116 | VCGMAG | 447ED380-1A06-4AA9-B0A5-504F6AB66863 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.0472222222222222 | 0 | HOURS | 2017-03-27 06:57:10 | 2017-03-27 | 06:57:10 | 1 | 1 | 1 | 2 | 371 | 371 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 121 | VCGMAG | 00689D31-8491-4643-B3C8-45241FBBD47C | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.0383333333333333 | 0 | HOURS | 2017-03-27 06:57:42 | 2017-03-27 | 06:57:42 | 1 | 1 | 1 | 3 | 368 | 368 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 124 | VCGMAG | F82BCAAB-FD0C-457A-B584-1A25DF594D4F | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 0 | HOURS | 1 | 1 | 1 | NA | 370.333333333333 | 370.333333333333 | ms | AVERAGE | Y | NA | NA | Day 1 predose | 391.4 | NA | NA | NA | Placebo group | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.0755555555555556 | 0 | HOURS | 2017-03-27 06:55:28 | 2017-03-27 | 06:55:28 | 1 | 1 | 1 | 1 | 382.330489500743 | 382.330489500743 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 116 | VCGMAG | 447ED380-1A06-4AA9-B0A5-504F6AB66863 | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.0472222222222222 | 0 | HOURS | 2017-03-27 06:57:10 | 2017-03-27 | 06:57:10 | 1 | 1 | 1 | 2 | 378.284763633537 | 378.284763633537 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 121 | VCGMAG | 00689D31-8491-4643-B3C8-45241FBBD47C | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.0383333333333333 | 0 | HOURS | 2017-03-27 06:57:42 | 2017-03-27 | 06:57:42 | 1 | 1 | 1 | 3 | 381.280990115151 | 381.280990115151 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 124 | VCGMAG | F82BCAAB-FD0C-457A-B584-1A25DF594D4F | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 0 | HOURS | 1 | 1 | 1 | NA | 380.632081083144 | 380.632081083144 | ms | AVERAGE | Y | NA | NA | Day 1 predose | 386.546840978442 | NA | NA | NA | Placebo group | NA | VCGMAG | QTCF>=450 | N | QTCF>=500 | N | ||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.0755555555555556 | 0 | HOURS | 2017-03-27 06:55:28 | 2017-03-27 | 06:55:28 | 1 | 1 | 1 | 1 | 921.111111111111 | 921.111111111111 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 116 | GLOBAL | 447ED380-1A06-4AA9-B0A5-504F6AB66863 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.0472222222222222 | 0 | HOURS | 2017-03-27 06:57:10 | 2017-03-27 | 06:57:10 | 1 | 1 | 1 | 2 | 943.333333333333 | 943.333333333333 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 121 | GLOBAL | 00689D31-8491-4643-B3C8-45241FBBD47C | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.0383333333333333 | 0 | HOURS | 2017-03-27 06:57:42 | 2017-03-27 | 06:57:42 | 1 | 1 | 1 | 3 | 899.1 | 899.1 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 124 | GLOBAL | F82BCAAB-FD0C-457A-B584-1A25DF594D4F | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 0 | HOURS | 1 | 1 | 1 | NA | 921.181481481481 | 921.181481481481 | ms | AVERAGE | Y | NA | NA | Day 1 predose | 1042.67556878307 | NA | NA | NA | Placebo group | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.0755555555555556 | 0 | HOURS | 2017-03-27 06:55:28 | 2017-03-27 | 06:55:28 | 1 | 1 | 1 | 1 | 61 | 61 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 116 | VCGMAG | 447ED380-1A06-4AA9-B0A5-504F6AB66863 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.0472222222222222 | 0 | HOURS | 2017-03-27 06:57:10 | 2017-03-27 | 06:57:10 | 1 | 1 | 1 | 2 | 61 | 61 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 121 | VCGMAG | 00689D31-8491-4643-B3C8-45241FBBD47C | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | -0.0383333333333333 | 0 | HOURS | 2017-03-27 06:57:42 | 2017-03-27 | 06:57:42 | 1 | 1 | 1 | 3 | 60 | 60 | ms | Y | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | 124 | VCGMAG | F82BCAAB-FD0C-457A-B584-1A25DF594D4F | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 0 hrs | 3 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 0 | HOURS | 1 | 1 | 1 | NA | 60.6666666666667 | 60.6666666666667 | ms | AVERAGE | Y | NA | NA | Day 1 predose | 71.6 | NA | NA | NA | Placebo group | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | Baseline | 4 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 0 | HOURS | 1 | 1 | 1 | NA | 67.3333333333333 | 67.3333333333333 | bpm | AVERAGE | Y | 67.3333333333333 | 0 | Day 1 predose | 58.6333333333333 | 58.6333333333333 | 0 | 0 | Placebo group | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | Baseline | 4 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 0 | HOURS | 1 | 1 | 1 | NA | 227.666666666667 | 227.666666666667 | ms | AVERAGE | Y | 227.666666666667 | 0 | Day 1 predose | 232.961111111111 | 232.961111111111 | 0 | 0 | Placebo group | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | Baseline | 4 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 0 | HOURS | 1 | 1 | 1 | NA | 243.068287022766 | 243.068287022766 | ms | AVERAGE | Y | 243.068287022766 | 0 | Day 1 predose | 229.45218001994 | 229.45218001994 | 0 | 0 | Placebo group | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | Baseline | 4 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 0 | HOURS | 1 | 1 | 1 | NA | 187.555555555556 | 187.555555555556 | ms | AVERAGE | Y | 187.555555555556 | 0 | Day 1 predose | 164.394444444444 | 164.394444444444 | 0 | 0 | Placebo group | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | Baseline | 4 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 0 | HOURS | 1 | 1 | 1 | NA | 78.7777777777778 | 78.7777777777778 | ms | AVERAGE | Y | 78.7777777777778 | 0 | Day 1 predose | 85.3666666666667 | 85.3666666666667 | 0 | 0 | Placebo group | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | Baseline | 4 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 0 | HOURS | 1 | 1 | 1 | NA | 366.555555555556 | 366.555555555556 | ms | AVERAGE | Y | 366.555555555556 | 0 | Day 1 predose | 390.855555555556 | 390.855555555556 | 0 | 0 | Placebo group | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | Baseline | 4 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 0 | HOURS | 1 | 1 | 1 | NA | 380.610483970258 | 380.610483970258 | ms | AVERAGE | Y | 380.610483970258 | 0 | Day 1 predose | 387.122499004314 | 387.122499004314 | 0 | 0 | Placebo group | NA | VCGMAG | QTCF>=450 | N | QTCF>=500 | N | ||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | Baseline | 4 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 0 | HOURS | 1 | 1 | 1 | NA | 893.921099887766 | 893.921099887766 | ms | AVERAGE | Y | 893.921099887766 | 0 | Day 1 predose | 1034.25331128748 | 1034.25331128748 | 0 | 0 | Placebo group | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | Baseline | 4 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 0 | HOURS | 1 | 1 | 1 | NA | 60.1111111111111 | 60.1111111111111 | ms | AVERAGE | Y | 60.1111111111111 | 0 | Day 1 predose | 72.5277777777778 | 72.5277777777778 | 0 | 0 | Placebo group | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 0.406388888888889 | 0.5 | HOURS | 2017-03-27 07:24:23 | 2017-03-27 | 07:24:23 | 1 | 1 | 1 | 1 | 75 | 75 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 192 | GLOBAL | BEF194AF-43DB-494F-B379-D6B288AA6294 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 0.414444444444444 | 0.5 | HOURS | 2017-03-27 07:24:52 | 2017-03-27 | 07:24:52 | 1 | 1 | 1 | 2 | 80 | 80 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 193 | GLOBAL | 40E98DEE-8E5A-4AC8-B784-912418BB430D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 0.431111111111111 | 0.5 | HOURS | 2017-03-27 07:25:52 | 2017-03-27 | 07:25:52 | 1 | 1 | 1 | 3 | 73 | 73 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 194 | GLOBAL | 1AF640A2-DBE9-453F-B3C2-C30D7E869348 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 0.5 | HOURS | 1 | 1 | 1 | NA | 76 | 76 | bpm | AVERAGE | 67.3333333333333 | 8.66666666666667 | Day 1 predose | 57.2666666666667 | 58.6333333333333 | -1.36666666666667 | 10.0333333333333 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 0.406388888888889 | 0.5 | HOURS | 2017-03-27 07:24:23 | 2017-03-27 | 07:24:23 | 1 | 1 | 1 | 1 | 213 | 213 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 192 | VCGMAG | BEF194AF-43DB-494F-B379-D6B288AA6294 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 0.414444444444444 | 0.5 | HOURS | 2017-03-27 07:24:52 | 2017-03-27 | 07:24:52 | 1 | 1 | 1 | 2 | 208 | 208 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 193 | VCGMAG | 40E98DEE-8E5A-4AC8-B784-912418BB430D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 0.431111111111111 | 0.5 | HOURS | 2017-03-27 07:25:52 | 2017-03-27 | 07:25:52 | 1 | 1 | 1 | 3 | 211 | 211 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 194 | VCGMAG | 1AF640A2-DBE9-453F-B3C2-C30D7E869348 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 0.5 | HOURS | 1 | 1 | 1 | NA | 210.666666666667 | 210.666666666667 | ms | AVERAGE | 227.666666666667 | -17 | Day 1 predose | 233.533333333333 | 232.961111111111 | 0.572222222222223 | -17.5722222222222 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 0.406388888888889 | 0.5 | HOURS | 2017-03-27 07:24:23 | 2017-03-27 | 07:24:23 | 1 | 1 | 1 | 1 | 242.123532586372 | 242.123532586372 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 192 | VCGMAG | BEF194AF-43DB-494F-B379-D6B288AA6294 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 0.414444444444444 | 0.5 | HOURS | 2017-03-27 07:24:52 | 2017-03-27 | 07:24:52 | 1 | 1 | 1 | 2 | 245.346406012338 | 245.346406012338 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 193 | VCGMAG | 40E98DEE-8E5A-4AC8-B784-912418BB430D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 0.431111111111111 | 0.5 | HOURS | 2017-03-27 07:25:52 | 2017-03-27 | 07:25:52 | 1 | 1 | 1 | 3 | 236.906944940474 | 236.906944940474 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 194 | VCGMAG | 1AF640A2-DBE9-453F-B3C2-C30D7E869348 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 0.5 | HOURS | 1 | 1 | 1 | NA | 241.458961179728 | 241.458961179728 | ms | AVERAGE | 243.068287022766 | -1.60932584303822 | Day 1 predose | 227.086564362544 | 229.45218001994 | -2.36561565739564 | 0.756289814357416 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 0.406388888888889 | 0.5 | HOURS | 2017-03-27 07:24:23 | 2017-03-27 | 07:24:23 | 1 | 1 | 1 | 1 | 183 | 183 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 192 | GLOBAL | BEF194AF-43DB-494F-B379-D6B288AA6294 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 0.414444444444444 | 0.5 | HOURS | 2017-03-27 07:24:52 | 2017-03-27 | 07:24:52 | 1 | 1 | 1 | 2 | 179 | 179 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 193 | GLOBAL | 40E98DEE-8E5A-4AC8-B784-912418BB430D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 0.431111111111111 | 0.5 | HOURS | 2017-03-27 07:25:52 | 2017-03-27 | 07:25:52 | 1 | 1 | 1 | 3 | 185 | 185 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 194 | GLOBAL | 1AF640A2-DBE9-453F-B3C2-C30D7E869348 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 0.5 | HOURS | 1 | 1 | 1 | NA | 182.333333333333 | 182.333333333333 | ms | AVERAGE | 187.555555555556 | -5.2222222222222 | Day 1 predose | 165 | 164.394444444444 | 0.605555555555554 | -5.82777777777775 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 0.406388888888889 | 0.5 | HOURS | 2017-03-27 07:24:23 | 2017-03-27 | 07:24:23 | 1 | 1 | 1 | 1 | 82 | 82 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 192 | VCGMAG | BEF194AF-43DB-494F-B379-D6B288AA6294 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 0.414444444444444 | 0.5 | HOURS | 2017-03-27 07:24:52 | 2017-03-27 | 07:24:52 | 1 | 1 | 1 | 2 | 84 | 84 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 193 | VCGMAG | 40E98DEE-8E5A-4AC8-B784-912418BB430D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 0.431111111111111 | 0.5 | HOURS | 2017-03-27 07:25:52 | 2017-03-27 | 07:25:52 | 1 | 1 | 1 | 3 | 82 | 82 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 194 | VCGMAG | 1AF640A2-DBE9-453F-B3C2-C30D7E869348 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 0.5 | HOURS | 1 | 1 | 1 | NA | 82.6666666666667 | 82.6666666666667 | ms | AVERAGE | 78.7777777777778 | 3.8888888888889 | Day 1 predose | 86.3 | 85.3666666666667 | 0.933333333333337 | 2.95555555555556 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 0.406388888888889 | 0.5 | HOURS | 2017-03-27 07:24:23 | 2017-03-27 | 07:24:23 | 1 | 1 | 1 | 1 | 352 | 352 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 192 | VCGMAG | BEF194AF-43DB-494F-B379-D6B288AA6294 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 0.414444444444444 | 0.5 | HOURS | 2017-03-27 07:24:52 | 2017-03-27 | 07:24:52 | 1 | 1 | 1 | 2 | 347 | 347 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 193 | VCGMAG | 40E98DEE-8E5A-4AC8-B784-912418BB430D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 0.431111111111111 | 0.5 | HOURS | 2017-03-27 07:25:52 | 2017-03-27 | 07:25:52 | 1 | 1 | 1 | 3 | 350 | 350 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 194 | VCGMAG | 1AF640A2-DBE9-453F-B3C2-C30D7E869348 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 0.5 | HOURS | 1 | 1 | 1 | NA | 349.666666666667 | 349.666666666667 | ms | AVERAGE | 366.555555555556 | -16.8888888888889 | Day 1 predose | 390.3 | 390.855555555556 | -0.555555555555543 | -16.3333333333333 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 0.406388888888889 | 0.5 | HOURS | 2017-03-27 07:24:23 | 2017-03-27 | 07:24:23 | 1 | 1 | 1 | 1 | 378.904422184061 | 378.904422184061 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 192 | VCGMAG | BEF194AF-43DB-494F-B379-D6B288AA6294 | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 0.414444444444444 | 0.5 | HOURS | 2017-03-27 07:24:52 | 2017-03-27 | 07:24:52 | 1 | 1 | 1 | 2 | 381.545008947213 | 381.545008947213 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 193 | VCGMAG | 40E98DEE-8E5A-4AC8-B784-912418BB430D | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 0.431111111111111 | 0.5 | HOURS | 2017-03-27 07:25:52 | 2017-03-27 | 07:25:52 | 1 | 1 | 1 | 3 | 374.087684147019 | 374.087684147019 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 194 | VCGMAG | 1AF640A2-DBE9-453F-B3C2-C30D7E869348 | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 0.5 | HOURS | 1 | 1 | 1 | NA | 378.179038426098 | 378.179038426098 | ms | AVERAGE | 380.610483970258 | -2.43144554416045 | Day 1 predose | 383.874341143008 | 387.122499004314 | -3.24815786130586 | 0.816712317145402 | Placebo group | Y | NA | VCGMAG | QTCF>=450 | N | QTCF>=500 | N | ||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 0.406388888888889 | 0.5 | HOURS | 2017-03-27 07:24:23 | 2017-03-27 | 07:24:23 | 1 | 1 | 1 | 1 | 801.75 | 801.75 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 192 | GLOBAL | BEF194AF-43DB-494F-B379-D6B288AA6294 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 0.414444444444444 | 0.5 | HOURS | 2017-03-27 07:24:52 | 2017-03-27 | 07:24:52 | 1 | 1 | 1 | 2 | 752.230769230769 | 752.230769230769 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 193 | GLOBAL | 40E98DEE-8E5A-4AC8-B784-912418BB430D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 0.431111111111111 | 0.5 | HOURS | 2017-03-27 07:25:52 | 2017-03-27 | 07:25:52 | 1 | 1 | 1 | 3 | 819 | 819 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 194 | GLOBAL | 1AF640A2-DBE9-453F-B3C2-C30D7E869348 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 0.5 | HOURS | 1 | 1 | 1 | NA | 790.99358974359 | 790.99358974359 | ms | AVERAGE | 893.921099887766 | -102.927510144177 | Day 1 predose | 1052.82751322751 | 1034.25331128748 | 18.5742019400354 | -121.501712084212 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 0.406388888888889 | 0.5 | HOURS | 2017-03-27 07:24:23 | 2017-03-27 | 07:24:23 | 1 | 1 | 1 | 1 | 57 | 57 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 192 | VCGMAG | BEF194AF-43DB-494F-B379-D6B288AA6294 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 0.414444444444444 | 0.5 | HOURS | 2017-03-27 07:24:52 | 2017-03-27 | 07:24:52 | 1 | 1 | 1 | 2 | 55 | 55 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 193 | VCGMAG | 40E98DEE-8E5A-4AC8-B784-912418BB430D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 0.431111111111111 | 0.5 | HOURS | 2017-03-27 07:25:52 | 2017-03-27 | 07:25:52 | 1 | 1 | 1 | 3 | 57 | 57 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 194 | VCGMAG | 1AF640A2-DBE9-453F-B3C2-C30D7E869348 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 0.5 hrs | 5 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 0.5 | HOURS | 1 | 1 | 1 | NA | 56.3333333333333 | 56.3333333333333 | ms | AVERAGE | 60.1111111111111 | -3.77777777777778 | Day 1 predose | 70.4666666666667 | 72.5277777777778 | -2.06111111111112 | -1.71666666666666 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 1.91722222222222 | 2 | HOURS | 2017-03-27 08:55:02 | 2017-03-27 | 08:55:02 | 1 | 1 | 1 | 1 | 78 | 78 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 298 | GLOBAL | 417205CA-70F3-4CFB-B0CE-4CB1691AF1E2 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 1.9425 | 2 | HOURS | 2017-03-27 08:56:33 | 2017-03-27 | 08:56:33 | 1 | 1 | 1 | 2 | 73 | 73 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 299 | GLOBAL | DF169BE9-CBA8-4BD1-9072-7B7F6462EBD0 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 1.95222222222222 | 2 | HOURS | 2017-03-27 08:57:08 | 2017-03-27 | 08:57:08 | 1 | 1 | 1 | 3 | 71 | 71 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 301 | GLOBAL | FB83E0D5-8065-4323-91F9-88CA045D717D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 2 | HOURS | 1 | 1 | 1 | NA | 74 | 74 | bpm | AVERAGE | 67.3333333333333 | 6.66666666666667 | Day 1 predose | 61.8 | 58.6333333333333 | 3.16666666666667 | 3.5 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 1.91722222222222 | 2 | HOURS | 2017-03-27 08:55:02 | 2017-03-27 | 08:55:02 | 1 | 1 | 1 | 1 | 196 | 196 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 298 | VCGMAG | 417205CA-70F3-4CFB-B0CE-4CB1691AF1E2 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 1.9425 | 2 | HOURS | 2017-03-27 08:56:33 | 2017-03-27 | 08:56:33 | 1 | 1 | 1 | 2 | 199 | 199 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 299 | VCGMAG | DF169BE9-CBA8-4BD1-9072-7B7F6462EBD0 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 1.95222222222222 | 2 | HOURS | 2017-03-27 08:57:08 | 2017-03-27 | 08:57:08 | 1 | 1 | 1 | 3 | 200 | 200 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 301 | VCGMAG | FB83E0D5-8065-4323-91F9-88CA045D717D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 2 | HOURS | 1 | 1 | 1 | NA | 198.333333333333 | 198.333333333333 | ms | AVERAGE | 227.666666666667 | -29.3333333333333 | Day 1 predose | 204.466666666667 | 232.961111111111 | -28.4944444444444 | -0.838888888888874 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 1.91722222222222 | 2 | HOURS | 2017-03-27 08:55:02 | 2017-03-27 | 08:55:02 | 1 | 1 | 1 | 1 | 228.498451005981 | 228.498451005981 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 298 | VCGMAG | 417205CA-70F3-4CFB-B0CE-4CB1691AF1E2 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 1.9425 | 2 | HOURS | 2017-03-27 08:56:33 | 2017-03-27 | 08:56:33 | 1 | 1 | 1 | 2 | 222.34637990878 | 222.34637990878 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 299 | VCGMAG | DF169BE9-CBA8-4BD1-9072-7B7F6462EBD0 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 1.95222222222222 | 2 | HOURS | 2017-03-27 08:57:08 | 2017-03-27 | 08:57:08 | 1 | 1 | 1 | 3 | 221.338558388268 | 221.338558388268 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 301 | VCGMAG | FB83E0D5-8065-4323-91F9-88CA045D717D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 2 | HOURS | 1 | 1 | 1 | NA | 224.061129767676 | 224.061129767676 | ms | AVERAGE | 243.068287022766 | -19.0071572550899 | Day 1 predose | 207.344384931213 | 229.45218001994 | -22.1077950887272 | 3.10063783363736 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 1.91722222222222 | 2 | HOURS | 2017-03-27 08:55:02 | 2017-03-27 | 08:55:02 | 1 | 1 | 1 | 1 | 180 | 180 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 298 | GLOBAL | 417205CA-70F3-4CFB-B0CE-4CB1691AF1E2 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 1.9425 | 2 | HOURS | 2017-03-27 08:56:33 | 2017-03-27 | 08:56:33 | 1 | 1 | 1 | 2 | 184 | 184 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 299 | GLOBAL | DF169BE9-CBA8-4BD1-9072-7B7F6462EBD0 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 1.95222222222222 | 2 | HOURS | 2017-03-27 08:57:08 | 2017-03-27 | 08:57:08 | 1 | 1 | 1 | 3 | 184 | 184 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 301 | GLOBAL | FB83E0D5-8065-4323-91F9-88CA045D717D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 2 | HOURS | 1 | 1 | 1 | NA | 182.666666666667 | 182.666666666667 | ms | AVERAGE | 187.555555555556 | -4.88888888888889 | Day 1 predose | 162.8 | 164.394444444444 | -1.59444444444443 | -3.29444444444445 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 1.91722222222222 | 2 | HOURS | 2017-03-27 08:55:02 | 2017-03-27 | 08:55:02 | 1 | 1 | 1 | 1 | 92 | 92 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 298 | VCGMAG | 417205CA-70F3-4CFB-B0CE-4CB1691AF1E2 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 1.9425 | 2 | HOURS | 2017-03-27 08:56:33 | 2017-03-27 | 08:56:33 | 1 | 1 | 1 | 2 | 89 | 89 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 299 | VCGMAG | DF169BE9-CBA8-4BD1-9072-7B7F6462EBD0 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 1.95222222222222 | 2 | HOURS | 2017-03-27 08:57:08 | 2017-03-27 | 08:57:08 | 1 | 1 | 1 | 3 | 89 | 89 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 301 | VCGMAG | FB83E0D5-8065-4323-91F9-88CA045D717D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 2 | HOURS | 1 | 1 | 1 | NA | 90 | 90 | ms | AVERAGE | 78.7777777777778 | 11.2222222222222 | Day 1 predose | 88.5666666666667 | 85.3666666666667 | 3.2 | 8.02222222222223 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 1.91722222222222 | 2 | HOURS | 2017-03-27 08:55:02 | 2017-03-27 | 08:55:02 | 1 | 1 | 1 | 1 | 350 | 350 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 298 | VCGMAG | 417205CA-70F3-4CFB-B0CE-4CB1691AF1E2 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 1.9425 | 2 | HOURS | 2017-03-27 08:56:33 | 2017-03-27 | 08:56:33 | 1 | 1 | 1 | 2 | 352 | 352 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 299 | VCGMAG | DF169BE9-CBA8-4BD1-9072-7B7F6462EBD0 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 1.95222222222222 | 2 | HOURS | 2017-03-27 08:57:08 | 2017-03-27 | 08:57:08 | 1 | 1 | 1 | 3 | 351 | 351 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 301 | VCGMAG | FB83E0D5-8065-4323-91F9-88CA045D717D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 2 | HOURS | 1 | 1 | 1 | NA | 351 | 351 | ms | AVERAGE | 366.555555555556 | -15.5555555555555 | Day 1 predose | 377.1 | 390.855555555556 | -13.7555555555555 | -1.80000000000001 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 1.91722222222222 | 2 | HOURS | 2017-03-27 08:55:02 | 2017-03-27 | 08:55:02 | 1 | 1 | 1 | 1 | 382.260595709724 | 382.260595709724 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 298 | VCGMAG | 417205CA-70F3-4CFB-B0CE-4CB1691AF1E2 | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 1.9425 | 2 | HOURS | 2017-03-27 08:56:33 | 2017-03-27 | 08:56:33 | 1 | 1 | 1 | 2 | 375.172145405777 | 375.172145405777 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 299 | VCGMAG | DF169BE9-CBA8-4BD1-9072-7B7F6462EBD0 | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 1.95222222222222 | 2 | HOURS | 2017-03-27 08:57:08 | 2017-03-27 | 08:57:08 | 1 | 1 | 1 | 3 | 372.057477061533 | 372.057477061533 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 301 | VCGMAG | FB83E0D5-8065-4323-91F9-88CA045D717D | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 2 | HOURS | 1 | 1 | 1 | NA | 376.496739392345 | 376.496739392345 | ms | AVERAGE | 380.610483970258 | -4.11374457791345 | Day 1 predose | 380.107892012284 | 387.122499004314 | -7.01460699203039 | 2.90086241411694 | Placebo group | Y | NA | VCGMAG | QTCF>=450 | N | QTCF>=500 | N | ||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 1.91722222222222 | 2 | HOURS | 2017-03-27 08:55:02 | 2017-03-27 | 08:55:02 | 1 | 1 | 1 | 1 | 767.583333333333 | 767.583333333333 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 298 | GLOBAL | 417205CA-70F3-4CFB-B0CE-4CB1691AF1E2 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 1.9425 | 2 | HOURS | 2017-03-27 08:56:33 | 2017-03-27 | 08:56:33 | 1 | 1 | 1 | 2 | 825.916666666667 | 825.916666666667 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 299 | GLOBAL | DF169BE9-CBA8-4BD1-9072-7B7F6462EBD0 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 1.95222222222222 | 2 | HOURS | 2017-03-27 08:57:08 | 2017-03-27 | 08:57:08 | 1 | 1 | 1 | 3 | 839.636363636364 | 839.636363636364 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 301 | GLOBAL | FB83E0D5-8065-4323-91F9-88CA045D717D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 2 | HOURS | 1 | 1 | 1 | NA | 811.045454545455 | 811.045454545455 | ms | AVERAGE | 893.921099887766 | -82.8756453423118 | Day 1 predose | 981.759190716691 | 1034.25331128748 | -52.4941205707868 | -30.3815247715251 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 1.91722222222222 | 2 | HOURS | 2017-03-27 08:55:02 | 2017-03-27 | 08:55:02 | 1 | 1 | 1 | 1 | 62 | 62 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 298 | VCGMAG | 417205CA-70F3-4CFB-B0CE-4CB1691AF1E2 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 1.9425 | 2 | HOURS | 2017-03-27 08:56:33 | 2017-03-27 | 08:56:33 | 1 | 1 | 1 | 2 | 64 | 64 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 299 | VCGMAG | DF169BE9-CBA8-4BD1-9072-7B7F6462EBD0 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 1.95222222222222 | 2 | HOURS | 2017-03-27 08:57:08 | 2017-03-27 | 08:57:08 | 1 | 1 | 1 | 3 | 62 | 62 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 301 | VCGMAG | FB83E0D5-8065-4323-91F9-88CA045D717D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 2 hrs | 6 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 2 | HOURS | 1 | 1 | 1 | NA | 62.6666666666667 | 62.6666666666667 | ms | AVERAGE | 60.1111111111111 | 2.55555555555555 | Day 1 predose | 84.0666666666667 | 72.5277777777778 | 11.5388888888889 | -8.98333333333333 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 2.44083333333333 | 2.5 | HOURS | 2017-03-27 09:26:27 | 2017-03-27 | 09:26:27 | 1 | 1 | 1 | 1 | 75 | 75 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 345 | GLOBAL | 087E807B-0680-4A5F-B89F-B85250AF2429 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 2.46694444444444 | 2.5 | HOURS | 2017-03-27 09:28:01 | 2017-03-27 | 09:28:01 | 1 | 1 | 1 | 2 | 71 | 71 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 347 | GLOBAL | 219FF449-1243-496C-9302-E1A2F4518AC6 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 2.47638888888889 | 2.5 | HOURS | 2017-03-27 09:28:35 | 2017-03-27 | 09:28:35 | 1 | 1 | 1 | 3 | 68 | 68 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 350 | GLOBAL | BB892D4E-0BF9-449D-8D8F-D76945587975 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 2.5 | HOURS | 1 | 1 | 1 | NA | 71.3333333333333 | 71.3333333333333 | bpm | AVERAGE | 67.3333333333333 | 4 | Day 1 predose | 64.0333333333333 | 58.6333333333333 | 5.4 | -1.4 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 2.44083333333333 | 2.5 | HOURS | 2017-03-27 09:26:27 | 2017-03-27 | 09:26:27 | 1 | 1 | 1 | 1 | 198 | 198 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 345 | VCGMAG | 087E807B-0680-4A5F-B89F-B85250AF2429 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 2.46694444444444 | 2.5 | HOURS | 2017-03-27 09:28:01 | 2017-03-27 | 09:28:01 | 1 | 1 | 1 | 2 | 206 | 206 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 347 | VCGMAG | 219FF449-1243-496C-9302-E1A2F4518AC6 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 2.47638888888889 | 2.5 | HOURS | 2017-03-27 09:28:35 | 2017-03-27 | 09:28:35 | 1 | 1 | 1 | 3 | 206 | 206 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 350 | VCGMAG | BB892D4E-0BF9-449D-8D8F-D76945587975 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 2.5 | HOURS | 1 | 1 | 1 | NA | 203.333333333333 | 203.333333333333 | ms | AVERAGE | 227.666666666667 | -24.3333333333333 | Day 1 predose | 211.433333333333 | 232.961111111111 | -21.5277777777778 | -2.80555555555554 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 2.44083333333333 | 2.5 | HOURS | 2017-03-27 09:26:27 | 2017-03-27 | 09:26:27 | 1 | 1 | 1 | 1 | 225.167613392221 | 225.167613392221 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 345 | VCGMAG | 087E807B-0680-4A5F-B89F-B85250AF2429 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 2.46694444444444 | 2.5 | HOURS | 2017-03-27 09:28:01 | 2017-03-27 | 09:28:01 | 1 | 1 | 1 | 2 | 226.643685847283 | 226.643685847283 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 347 | VCGMAG | 219FF449-1243-496C-9302-E1A2F4518AC6 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 2.47638888888889 | 2.5 | HOURS | 2017-03-27 09:28:35 | 2017-03-27 | 09:28:35 | 1 | 1 | 1 | 3 | 222.227057631353 | 222.227057631353 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 350 | VCGMAG | BB892D4E-0BF9-449D-8D8F-D76945587975 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 2.5 | HOURS | 1 | 1 | 1 | NA | 224.679452290286 | 224.679452290286 | ms | AVERAGE | 243.068287022766 | -18.3888347324805 | Day 1 predose | 218.563489026199 | 229.45218001994 | -10.8886909937413 | -7.50014373873921 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 2.44083333333333 | 2.5 | HOURS | 2017-03-27 09:26:27 | 2017-03-27 | 09:26:27 | 1 | 1 | 1 | 1 | 183 | 183 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 345 | GLOBAL | 087E807B-0680-4A5F-B89F-B85250AF2429 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 2.46694444444444 | 2.5 | HOURS | 2017-03-27 09:28:01 | 2017-03-27 | 09:28:01 | 1 | 1 | 1 | 2 | 183 | 183 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 347 | GLOBAL | 219FF449-1243-496C-9302-E1A2F4518AC6 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 2.47638888888889 | 2.5 | HOURS | 2017-03-27 09:28:35 | 2017-03-27 | 09:28:35 | 1 | 1 | 1 | 3 | 181 | 181 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 350 | GLOBAL | BB892D4E-0BF9-449D-8D8F-D76945587975 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 2.5 | HOURS | 1 | 1 | 1 | NA | 182.333333333333 | 182.333333333333 | ms | AVERAGE | 187.555555555556 | -5.2222222222222 | Day 1 predose | 162.5 | 164.394444444444 | -1.89444444444445 | -3.32777777777775 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 2.44083333333333 | 2.5 | HOURS | 2017-03-27 09:26:27 | 2017-03-27 | 09:26:27 | 1 | 1 | 1 | 1 | 85 | 85 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 345 | VCGMAG | 087E807B-0680-4A5F-B89F-B85250AF2429 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 2.46694444444444 | 2.5 | HOURS | 2017-03-27 09:28:01 | 2017-03-27 | 09:28:01 | 1 | 1 | 1 | 2 | 84 | 84 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 347 | VCGMAG | 219FF449-1243-496C-9302-E1A2F4518AC6 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 2.47638888888889 | 2.5 | HOURS | 2017-03-27 09:28:35 | 2017-03-27 | 09:28:35 | 1 | 1 | 1 | 3 | 84 | 84 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 350 | VCGMAG | BB892D4E-0BF9-449D-8D8F-D76945587975 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 2.5 | HOURS | 1 | 1 | 1 | NA | 84.3333333333333 | 84.3333333333333 | ms | AVERAGE | 78.7777777777778 | 5.55555555555556 | Day 1 predose | 85.8666666666667 | 85.3666666666667 | 0.500000000000014 | 5.05555555555554 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 2.44083333333333 | 2.5 | HOURS | 2017-03-27 09:26:27 | 2017-03-27 | 09:26:27 | 1 | 1 | 1 | 1 | 342 | 342 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 345 | VCGMAG | 087E807B-0680-4A5F-B89F-B85250AF2429 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 2.46694444444444 | 2.5 | HOURS | 2017-03-27 09:28:01 | 2017-03-27 | 09:28:01 | 1 | 1 | 1 | 2 | 348 | 348 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 347 | VCGMAG | 219FF449-1243-496C-9302-E1A2F4518AC6 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 2.47638888888889 | 2.5 | HOURS | 2017-03-27 09:28:35 | 2017-03-27 | 09:28:35 | 1 | 1 | 1 | 3 | 349 | 349 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 350 | VCGMAG | BB892D4E-0BF9-449D-8D8F-D76945587975 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 2.5 | HOURS | 1 | 1 | 1 | NA | 346.333333333333 | 346.333333333333 | ms | AVERAGE | 366.555555555556 | -20.2222222222222 | Day 1 predose | 368.233333333333 | 390.855555555556 | -22.6222222222222 | 2.39999999999998 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 2.44083333333333 | 2.5 | HOURS | 2017-03-27 09:26:27 | 2017-03-27 | 09:26:27 | 1 | 1 | 1 | 1 | 368.229418527328 | 368.229418527328 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 345 | VCGMAG | 087E807B-0680-4A5F-B89F-B85250AF2429 | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 2.46694444444444 | 2.5 | HOURS | 2017-03-27 09:28:01 | 2017-03-27 | 09:28:01 | 1 | 1 | 1 | 2 | 367.634497915543 | 367.634497915543 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 347 | VCGMAG | 219FF449-1243-496C-9302-E1A2F4518AC6 | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 2.47638888888889 | 2.5 | HOURS | 2017-03-27 09:28:35 | 2017-03-27 | 09:28:35 | 1 | 1 | 1 | 3 | 364.544500547791 | 364.544500547791 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 350 | VCGMAG | BB892D4E-0BF9-449D-8D8F-D76945587975 | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 2.5 | HOURS | 1 | 1 | 1 | NA | 366.802805663554 | 366.802805663554 | ms | AVERAGE | 380.610483970258 | -13.8076783067041 | Day 1 predose | 375.053302474456 | 387.122499004314 | -12.0691965298574 | -1.73848177684664 | Placebo group | Y | NA | VCGMAG | QTCF>=450 | N | QTCF>=500 | N | ||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 2.44083333333333 | 2.5 | HOURS | 2017-03-27 09:26:27 | 2017-03-27 | 09:26:27 | 1 | 1 | 1 | 1 | 801.166666666667 | 801.166666666667 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 345 | GLOBAL | 087E807B-0680-4A5F-B89F-B85250AF2429 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 2.46694444444444 | 2.5 | HOURS | 2017-03-27 09:28:01 | 2017-03-27 | 09:28:01 | 1 | 1 | 1 | 2 | 848.181818181818 | 848.181818181818 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 347 | GLOBAL | 219FF449-1243-496C-9302-E1A2F4518AC6 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 2.47638888888889 | 2.5 | HOURS | 2017-03-27 09:28:35 | 2017-03-27 | 09:28:35 | 1 | 1 | 1 | 3 | 877.454545454545 | 877.454545454545 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 350 | GLOBAL | BB892D4E-0BF9-449D-8D8F-D76945587975 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 2.5 | HOURS | 1 | 1 | 1 | NA | 842.267676767677 | 842.267676767677 | ms | AVERAGE | 893.921099887766 | -51.6534231200898 | Day 1 predose | 949.484402356902 | 1034.25331128748 | -84.7689089305755 | 33.1154858104858 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 2.44083333333333 | 2.5 | HOURS | 2017-03-27 09:26:27 | 2017-03-27 | 09:26:27 | 1 | 1 | 1 | 1 | 59 | 59 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 345 | VCGMAG | 087E807B-0680-4A5F-B89F-B85250AF2429 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 2.46694444444444 | 2.5 | HOURS | 2017-03-27 09:28:01 | 2017-03-27 | 09:28:01 | 1 | 1 | 1 | 2 | 58 | 58 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 347 | VCGMAG | 219FF449-1243-496C-9302-E1A2F4518AC6 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 2.47638888888889 | 2.5 | HOURS | 2017-03-27 09:28:35 | 2017-03-27 | 09:28:35 | 1 | 1 | 1 | 3 | 59 | 59 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 350 | VCGMAG | BB892D4E-0BF9-449D-8D8F-D76945587975 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 2.5 hrs | 7 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 2.5 | HOURS | 1 | 1 | 1 | NA | 58.6666666666667 | 58.6666666666667 | ms | AVERAGE | 60.1111111111111 | -1.44444444444445 | Day 1 predose | 70.9333333333333 | 72.5277777777778 | -1.59444444444445 | 0.149999999999999 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 3.41416666666667 | 3.5 | HOURS | 2017-03-27 10:24:51 | 2017-03-27 | 10:24:51 | 1 | 1 | 1 | 1 | 71 | 71 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 448 | GLOBAL | 43AC3A91-2DA0-4D68-919B-EB95D790EE5D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 3.42277777777778 | 3.5 | HOURS | 2017-03-27 10:25:22 | 2017-03-27 | 10:25:22 | 1 | 1 | 1 | 2 | 69 | 69 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 449 | GLOBAL | 47F6C400-7076-45FF-81BF-8BF13BD42FC6 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 3.44416666666667 | 3.5 | HOURS | 2017-03-27 10:26:39 | 2017-03-27 | 10:26:39 | 1 | 1 | 1 | 3 | 75 | 75 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 450 | GLOBAL | AB857D92-55F2-48E1-8CF0-BA161C80FA42 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 3.5 | HOURS | 1 | 1 | 1 | NA | 71.6666666666667 | 71.6666666666667 | bpm | AVERAGE | 67.3333333333333 | 4.33333333333334 | Day 1 predose | 63.0333333333333 | 58.6333333333333 | 4.4 | -0.0666666666666558 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 3.41416666666667 | 3.5 | HOURS | 2017-03-27 10:24:51 | 2017-03-27 | 10:24:51 | 1 | 1 | 1 | 1 | 197 | 197 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 448 | VCGMAG | 43AC3A91-2DA0-4D68-919B-EB95D790EE5D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 3.42277777777778 | 3.5 | HOURS | 2017-03-27 10:25:22 | 2017-03-27 | 10:25:22 | 1 | 1 | 1 | 2 | 202 | 202 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 449 | VCGMAG | 47F6C400-7076-45FF-81BF-8BF13BD42FC6 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 3.44416666666667 | 3.5 | HOURS | 2017-03-27 10:26:39 | 2017-03-27 | 10:26:39 | 1 | 1 | 1 | 3 | 199 | 199 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 450 | VCGMAG | AB857D92-55F2-48E1-8CF0-BA161C80FA42 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 3.5 | HOURS | 1 | 1 | 1 | NA | 199.333333333333 | 199.333333333333 | ms | AVERAGE | 227.666666666667 | -28.3333333333333 | Day 1 predose | 213.333333333333 | 232.961111111111 | -19.6277777777778 | -8.70555555555555 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 3.41416666666667 | 3.5 | HOURS | 2017-03-27 10:24:51 | 2017-03-27 | 10:24:51 | 1 | 1 | 1 | 1 | 216.828056098036 | 216.828056098036 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 448 | VCGMAG | 43AC3A91-2DA0-4D68-919B-EB95D790EE5D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 3.42277777777778 | 3.5 | HOURS | 2017-03-27 10:25:22 | 2017-03-27 | 10:25:22 | 1 | 1 | 1 | 2 | 219.059373719565 | 219.059373719565 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 449 | VCGMAG | 47F6C400-7076-45FF-81BF-8BF13BD42FC6 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 3.44416666666667 | 3.5 | HOURS | 2017-03-27 10:26:39 | 2017-03-27 | 10:26:39 | 1 | 1 | 1 | 3 | 227.110497438463 | 227.110497438463 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 450 | VCGMAG | AB857D92-55F2-48E1-8CF0-BA161C80FA42 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 3.5 | HOURS | 1 | 1 | 1 | NA | 220.999309085355 | 220.999309085355 | ms | AVERAGE | 243.068287022766 | -22.0689779374115 | Day 1 predose | 218.443623304794 | 229.45218001994 | -11.0085567151463 | -11.0604212222653 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 3.41416666666667 | 3.5 | HOURS | 2017-03-27 10:24:51 | 2017-03-27 | 10:24:51 | 1 | 1 | 1 | 1 | 179 | 179 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 448 | GLOBAL | 43AC3A91-2DA0-4D68-919B-EB95D790EE5D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 3.42277777777778 | 3.5 | HOURS | 2017-03-27 10:25:22 | 2017-03-27 | 10:25:22 | 1 | 1 | 1 | 2 | 180 | 180 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 449 | GLOBAL | 47F6C400-7076-45FF-81BF-8BF13BD42FC6 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 3.44416666666667 | 3.5 | HOURS | 2017-03-27 10:26:39 | 2017-03-27 | 10:26:39 | 1 | 1 | 1 | 3 | 180 | 180 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 450 | GLOBAL | AB857D92-55F2-48E1-8CF0-BA161C80FA42 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 3.5 | HOURS | 1 | 1 | 1 | NA | 179.666666666667 | 179.666666666667 | ms | AVERAGE | 187.555555555556 | -7.88888888888889 | Day 1 predose | 161.1 | 164.394444444444 | -3.29444444444445 | -4.59444444444443 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 3.41416666666667 | 3.5 | HOURS | 2017-03-27 10:24:51 | 2017-03-27 | 10:24:51 | 1 | 1 | 1 | 1 | 92 | 92 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 448 | VCGMAG | 43AC3A91-2DA0-4D68-919B-EB95D790EE5D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 3.42277777777778 | 3.5 | HOURS | 2017-03-27 10:25:22 | 2017-03-27 | 10:25:22 | 1 | 1 | 1 | 2 | 91 | 91 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 449 | VCGMAG | 47F6C400-7076-45FF-81BF-8BF13BD42FC6 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 3.44416666666667 | 3.5 | HOURS | 2017-03-27 10:26:39 | 2017-03-27 | 10:26:39 | 1 | 1 | 1 | 3 | 91 | 91 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 450 | VCGMAG | AB857D92-55F2-48E1-8CF0-BA161C80FA42 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 3.5 | HOURS | 1 | 1 | 1 | NA | 91.3333333333333 | 91.3333333333333 | ms | AVERAGE | 78.7777777777778 | 12.5555555555556 | Day 1 predose | 84.7 | 85.3666666666667 | -0.666666666666657 | 13.2222222222222 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 3.41416666666667 | 3.5 | HOURS | 2017-03-27 10:24:51 | 2017-03-27 | 10:24:51 | 1 | 1 | 1 | 1 | 347 | 347 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 448 | VCGMAG | 43AC3A91-2DA0-4D68-919B-EB95D790EE5D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 3.42277777777778 | 3.5 | HOURS | 2017-03-27 10:25:22 | 2017-03-27 | 10:25:22 | 1 | 1 | 1 | 2 | 352 | 352 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 449 | VCGMAG | 47F6C400-7076-45FF-81BF-8BF13BD42FC6 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 3.44416666666667 | 3.5 | HOURS | 2017-03-27 10:26:39 | 2017-03-27 | 10:26:39 | 1 | 1 | 1 | 3 | 348 | 348 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 450 | VCGMAG | AB857D92-55F2-48E1-8CF0-BA161C80FA42 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 3.5 | HOURS | 1 | 1 | 1 | NA | 349 | 349 | ms | AVERAGE | 366.555555555556 | -17.5555555555555 | Day 1 predose | 365 | 390.855555555556 | -25.8555555555556 | 8.30000000000001 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 3.41416666666667 | 3.5 | HOURS | 2017-03-27 10:24:51 | 2017-03-27 | 10:24:51 | 1 | 1 | 1 | 1 | 366.661934506188 | 366.661934506188 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 448 | VCGMAG | 43AC3A91-2DA0-4D68-919B-EB95D790EE5D | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 3.42277777777778 | 3.5 | HOURS | 2017-03-27 10:25:22 | 2017-03-27 | 10:25:22 | 1 | 1 | 1 | 2 | 368.78951659756 | 368.78951659756 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 449 | VCGMAG | 47F6C400-7076-45FF-81BF-8BF13BD42FC6 | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 3.44416666666667 | 3.5 | HOURS | 2017-03-27 10:26:39 | 2017-03-27 | 10:26:39 | 1 | 1 | 1 | 3 | 375.455637962622 | 375.455637962622 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 450 | VCGMAG | AB857D92-55F2-48E1-8CF0-BA161C80FA42 | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 3.5 | HOURS | 1 | 1 | 1 | NA | 370.302363022123 | 370.302363022123 | ms | AVERAGE | 380.610483970258 | -10.3081209481347 | Day 1 predose | 369.602445989071 | 387.122499004314 | -17.5200530152433 | 7.21193206710853 | Placebo group | Y | NA | VCGMAG | QTCF>=450 | N | QTCF>=500 | N | ||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 3.41416666666667 | 3.5 | HOURS | 2017-03-27 10:24:51 | 2017-03-27 | 10:24:51 | 1 | 1 | 1 | 1 | 847.6 | 847.6 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 448 | GLOBAL | 43AC3A91-2DA0-4D68-919B-EB95D790EE5D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 3.42277777777778 | 3.5 | HOURS | 2017-03-27 10:25:22 | 2017-03-27 | 10:25:22 | 1 | 1 | 1 | 2 | 869.545454545455 | 869.545454545455 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 449 | GLOBAL | 47F6C400-7076-45FF-81BF-8BF13BD42FC6 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 3.44416666666667 | 3.5 | HOURS | 2017-03-27 10:26:39 | 2017-03-27 | 10:26:39 | 1 | 1 | 1 | 3 | 796.272727272727 | 796.272727272727 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 450 | GLOBAL | AB857D92-55F2-48E1-8CF0-BA161C80FA42 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 3.5 | HOURS | 1 | 1 | 1 | NA | 837.806060606061 | 837.806060606061 | ms | AVERAGE | 893.921099887766 | -56.1150392817058 | Day 1 predose | 967.690058922559 | 1034.25331128748 | -66.5632523649188 | 10.448213083213 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 3.41416666666667 | 3.5 | HOURS | 2017-03-27 10:24:51 | 2017-03-27 | 10:24:51 | 1 | 1 | 1 | 1 | 58 | 58 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 448 | VCGMAG | 43AC3A91-2DA0-4D68-919B-EB95D790EE5D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 3.42277777777778 | 3.5 | HOURS | 2017-03-27 10:25:22 | 2017-03-27 | 10:25:22 | 1 | 1 | 1 | 2 | 59 | 59 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 449 | VCGMAG | 47F6C400-7076-45FF-81BF-8BF13BD42FC6 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 3.44416666666667 | 3.5 | HOURS | 2017-03-27 10:26:39 | 2017-03-27 | 10:26:39 | 1 | 1 | 1 | 3 | 58 | 58 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 450 | VCGMAG | AB857D92-55F2-48E1-8CF0-BA161C80FA42 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 3.5 hrs | 8 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 3.5 | HOURS | 1 | 1 | 1 | NA | 58.3333333333333 | 58.3333333333333 | ms | AVERAGE | 60.1111111111111 | -1.77777777777778 | Day 1 predose | 66.9666666666667 | 72.5277777777778 | -5.56111111111112 | 3.78333333333334 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.42944444444444 | 4.5 | HOURS | 2017-03-27 11:25:46 | 2017-03-27 | 11:25:46 | 1 | 1 | 1 | 1 | 65 | 65 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 523 | GLOBAL | C6666879-469A-4827-934B-1E47B077EE41 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.44944444444444 | 4.5 | HOURS | 2017-03-27 11:26:58 | 2017-03-27 | 11:26:58 | 1 | 1 | 1 | 2 | 73 | 73 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 525 | GLOBAL | 193139B3-0A73-4FEC-A76E-DED6C267A6D7 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.46722222222222 | 4.5 | HOURS | 2017-03-27 11:28:02 | 2017-03-27 | 11:28:02 | 1 | 1 | 1 | 3 | 71 | 71 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 526 | GLOBAL | 51B1ED19-76C2-4F2D-8C0A-B1A6B14658FB | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 4.5 | HOURS | 1 | 1 | 1 | NA | 69.6666666666667 | 69.6666666666667 | bpm | AVERAGE | 67.3333333333333 | 2.33333333333334 | Day 1 predose | 61.5333333333333 | 58.6333333333333 | 2.9 | -0.566666666666656 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.42944444444444 | 4.5 | HOURS | 2017-03-27 11:25:46 | 2017-03-27 | 11:25:46 | 1 | 1 | 1 | 1 | 217 | 217 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 523 | VCGMAG | C6666879-469A-4827-934B-1E47B077EE41 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.44944444444444 | 4.5 | HOURS | 2017-03-27 11:26:58 | 2017-03-27 | 11:26:58 | 1 | 1 | 1 | 2 | 210 | 210 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 525 | VCGMAG | 193139B3-0A73-4FEC-A76E-DED6C267A6D7 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.46722222222222 | 4.5 | HOURS | 2017-03-27 11:28:02 | 2017-03-27 | 11:28:02 | 1 | 1 | 1 | 3 | 211 | 211 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 526 | VCGMAG | 51B1ED19-76C2-4F2D-8C0A-B1A6B14658FB | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 4.5 | HOURS | 1 | 1 | 1 | NA | 212.666666666667 | 212.666666666667 | ms | AVERAGE | 227.666666666667 | -15 | Day 1 predose | 215.866666666667 | 232.961111111111 | -17.0944444444444 | 2.09444444444443 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.42944444444444 | 4.5 | HOURS | 2017-03-27 11:25:46 | 2017-03-27 | 11:25:46 | 1 | 1 | 1 | 1 | 227.021648802316 | 227.021648802316 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 523 | VCGMAG | C6666879-469A-4827-934B-1E47B077EE41 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.44944444444444 | 4.5 | HOURS | 2017-03-27 11:26:58 | 2017-03-27 | 11:26:58 | 1 | 1 | 1 | 2 | 235.526490687428 | 235.526490687428 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 525 | VCGMAG | 193139B3-0A73-4FEC-A76E-DED6C267A6D7 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.46722222222222 | 4.5 | HOURS | 2017-03-27 11:28:02 | 2017-03-27 | 11:28:02 | 1 | 1 | 1 | 3 | 232.5352840814 | 232.5352840814 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 526 | VCGMAG | 51B1ED19-76C2-4F2D-8C0A-B1A6B14658FB | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 4.5 | HOURS | 1 | 1 | 1 | NA | 231.694474523715 | 231.694474523715 | ms | AVERAGE | 243.068287022766 | -11.3738124990516 | Day 1 predose | 218.097191151344 | 229.45218001994 | -11.3549888685958 | -0.0188236304557847 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.42944444444444 | 4.5 | HOURS | 2017-03-27 11:25:46 | 2017-03-27 | 11:25:46 | 1 | 1 | 1 | 1 | 178 | 178 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 523 | GLOBAL | C6666879-469A-4827-934B-1E47B077EE41 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.44944444444444 | 4.5 | HOURS | 2017-03-27 11:26:58 | 2017-03-27 | 11:26:58 | 1 | 1 | 1 | 2 | 178 | 178 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 525 | GLOBAL | 193139B3-0A73-4FEC-A76E-DED6C267A6D7 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.46722222222222 | 4.5 | HOURS | 2017-03-27 11:28:02 | 2017-03-27 | 11:28:02 | 1 | 1 | 1 | 3 | 180 | 180 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 526 | GLOBAL | 51B1ED19-76C2-4F2D-8C0A-B1A6B14658FB | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 4.5 | HOURS | 1 | 1 | 1 | NA | 178.666666666667 | 178.666666666667 | ms | AVERAGE | 187.555555555556 | -8.88888888888889 | Day 1 predose | 157.933333333333 | 164.394444444444 | -6.46111111111111 | -2.42777777777778 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.42944444444444 | 4.5 | HOURS | 2017-03-27 11:25:46 | 2017-03-27 | 11:25:46 | 1 | 1 | 1 | 1 | 83 | 83 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 523 | VCGMAG | C6666879-469A-4827-934B-1E47B077EE41 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.44944444444444 | 4.5 | HOURS | 2017-03-27 11:26:58 | 2017-03-27 | 11:26:58 | 1 | 1 | 1 | 2 | 87 | 87 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 525 | VCGMAG | 193139B3-0A73-4FEC-A76E-DED6C267A6D7 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.46722222222222 | 4.5 | HOURS | 2017-03-27 11:28:02 | 2017-03-27 | 11:28:02 | 1 | 1 | 1 | 3 | 85 | 85 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 526 | VCGMAG | 51B1ED19-76C2-4F2D-8C0A-B1A6B14658FB | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 4.5 | HOURS | 1 | 1 | 1 | NA | 85 | 85 | ms | AVERAGE | 78.7777777777778 | 6.22222222222223 | Day 1 predose | 86 | 85.3666666666667 | 0.63333333333334 | 5.58888888888889 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.42944444444444 | 4.5 | HOURS | 2017-03-27 11:25:46 | 2017-03-27 | 11:25:46 | 1 | 1 | 1 | 1 | 359 | 359 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 523 | VCGMAG | C6666879-469A-4827-934B-1E47B077EE41 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.44944444444444 | 4.5 | HOURS | 2017-03-27 11:26:58 | 2017-03-27 | 11:26:58 | 1 | 1 | 1 | 2 | 356 | 356 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 525 | VCGMAG | 193139B3-0A73-4FEC-A76E-DED6C267A6D7 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.46722222222222 | 4.5 | HOURS | 2017-03-27 11:28:02 | 2017-03-27 | 11:28:02 | 1 | 1 | 1 | 3 | 354 | 354 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 526 | VCGMAG | 51B1ED19-76C2-4F2D-8C0A-B1A6B14658FB | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 4.5 | HOURS | 1 | 1 | 1 | NA | 356.333333333333 | 356.333333333333 | ms | AVERAGE | 366.555555555556 | -10.2222222222222 | Day 1 predose | 371.033333333333 | 390.855555555556 | -19.8222222222222 | 9.59999999999997 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.42944444444444 | 4.5 | HOURS | 2017-03-27 11:25:46 | 2017-03-27 | 11:25:46 | 1 | 1 | 1 | 1 | 368.436925463088 | 368.436925463088 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 523 | VCGMAG | C6666879-469A-4827-934B-1E47B077EE41 | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.44944444444444 | 4.5 | HOURS | 2017-03-27 11:26:58 | 2017-03-27 | 11:26:58 | 1 | 1 | 1 | 2 | 380.261581391226 | 380.261581391226 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 525 | VCGMAG | 193139B3-0A73-4FEC-A76E-DED6C267A6D7 | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.46722222222222 | 4.5 | HOURS | 2017-03-27 11:28:02 | 2017-03-27 | 11:28:02 | 1 | 1 | 1 | 3 | 374.3344669664 | 374.3344669664 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 526 | VCGMAG | 51B1ED19-76C2-4F2D-8C0A-B1A6B14658FB | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 4.5 | HOURS | 1 | 1 | 1 | NA | 374.344324606905 | 374.344324606905 | ms | AVERAGE | 380.610483970258 | -6.26615936335344 | Day 1 predose | 372.870635873861 | 387.122499004314 | -14.2518631304527 | 7.98570376709927 | Placebo group | Y | NA | VCGMAG | QTCF>=450 | N | QTCF>=500 | N | ||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.42944444444444 | 4.5 | HOURS | 2017-03-27 11:25:46 | 2017-03-27 | 11:25:46 | 1 | 1 | 1 | 1 | 925.111111111111 | 925.111111111111 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 523 | GLOBAL | C6666879-469A-4827-934B-1E47B077EE41 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.44944444444444 | 4.5 | HOURS | 2017-03-27 11:26:58 | 2017-03-27 | 11:26:58 | 1 | 1 | 1 | 2 | 820.545454545455 | 820.545454545455 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 525 | GLOBAL | 193139B3-0A73-4FEC-A76E-DED6C267A6D7 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.46722222222222 | 4.5 | HOURS | 2017-03-27 11:28:02 | 2017-03-27 | 11:28:02 | 1 | 1 | 1 | 3 | 845.727272727273 | 845.727272727273 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 526 | GLOBAL | 51B1ED19-76C2-4F2D-8C0A-B1A6B14658FB | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 4.5 | HOURS | 1 | 1 | 1 | NA | 863.794612794613 | 863.794612794613 | ms | AVERAGE | 893.921099887766 | -30.1264870931535 | Day 1 predose | 990.228797498798 | 1034.25331128748 | -44.0245137886799 | 13.8980266955264 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.42944444444444 | 4.5 | HOURS | 2017-03-27 11:25:46 | 2017-03-27 | 11:25:46 | 1 | 1 | 1 | 1 | 59 | 59 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 523 | VCGMAG | C6666879-469A-4827-934B-1E47B077EE41 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.44944444444444 | 4.5 | HOURS | 2017-03-27 11:26:58 | 2017-03-27 | 11:26:58 | 1 | 1 | 1 | 2 | 59 | 59 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 525 | VCGMAG | 193139B3-0A73-4FEC-A76E-DED6C267A6D7 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.46722222222222 | 4.5 | HOURS | 2017-03-27 11:28:02 | 2017-03-27 | 11:28:02 | 1 | 1 | 1 | 3 | 58 | 58 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 526 | VCGMAG | 51B1ED19-76C2-4F2D-8C0A-B1A6B14658FB | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 4.5 hrs | 9 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 4.5 | HOURS | 1 | 1 | 1 | NA | 58.6666666666667 | 58.6666666666667 | ms | AVERAGE | 60.1111111111111 | -1.44444444444445 | Day 1 predose | 69.1666666666667 | 72.5277777777778 | -3.36111111111111 | 1.91666666666666 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.90194444444444 | 5 | HOURS | 2017-03-27 11:54:07 | 2017-03-27 | 11:54:07 | 1 | 1 | 1 | 1 | 69 | 69 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 567 | GLOBAL | 9442FCF2-329C-4EB5-A716-82FADAE43ADC | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.93027777777778 | 5 | HOURS | 2017-03-27 11:55:49 | 2017-03-27 | 11:55:49 | 1 | 1 | 1 | 2 | 63 | 63 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 569 | GLOBAL | 85A46375-3A0F-417E-B9EC-16515E805B8B | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.96583333333333 | 5 | HOURS | 2017-03-27 11:57:57 | 2017-03-27 | 11:57:57 | 1 | 1 | 1 | 3 | 66 | 66 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 573 | GLOBAL | F9EB2C08-FBD5-4715-8260-A2130D3DC4E3 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 5 | HOURS | 1 | 1 | 1 | NA | 66 | 66 | bpm | AVERAGE | 67.3333333333333 | -1.33333333333333 | Day 1 predose | 61.6 | 58.6333333333333 | 2.96666666666667 | -4.3 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.90194444444444 | 5 | HOURS | 2017-03-27 11:54:07 | 2017-03-27 | 11:54:07 | 1 | 1 | 1 | 1 | 209 | 209 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 567 | VCGMAG | 9442FCF2-329C-4EB5-A716-82FADAE43ADC | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.93027777777778 | 5 | HOURS | 2017-03-27 11:55:49 | 2017-03-27 | 11:55:49 | 1 | 1 | 1 | 2 | 214 | 214 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 569 | VCGMAG | 85A46375-3A0F-417E-B9EC-16515E805B8B | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.96583333333333 | 5 | HOURS | 2017-03-27 11:57:57 | 2017-03-27 | 11:57:57 | 1 | 1 | 1 | 3 | 215 | 215 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 573 | VCGMAG | F9EB2C08-FBD5-4715-8260-A2130D3DC4E3 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 5 | HOURS | 1 | 1 | 1 | NA | 212.666666666667 | 212.666666666667 | ms | AVERAGE | 227.666666666667 | -15 | Day 1 predose | 215.7 | 232.961111111111 | -17.2611111111111 | 2.26111111111112 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.90194444444444 | 5 | HOURS | 2017-03-27 11:54:07 | 2017-03-27 | 11:54:07 | 1 | 1 | 1 | 1 | 225.748379480912 | 225.748379480912 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 567 | VCGMAG | 9442FCF2-329C-4EB5-A716-82FADAE43ADC | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.93027777777778 | 5 | HOURS | 2017-03-27 11:55:49 | 2017-03-27 | 11:55:49 | 1 | 1 | 1 | 2 | 219.970146252008 | 219.970146252008 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 569 | VCGMAG | 85A46375-3A0F-417E-B9EC-16515E805B8B | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.96583333333333 | 5 | HOURS | 2017-03-27 11:57:57 | 2017-03-27 | 11:57:57 | 1 | 1 | 1 | 3 | 228.005002779875 | 228.005002779875 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 573 | VCGMAG | F9EB2C08-FBD5-4715-8260-A2130D3DC4E3 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 5 | HOURS | 1 | 1 | 1 | NA | 224.574509504265 | 224.574509504265 | ms | AVERAGE | 243.068287022766 | -18.4937775185012 | Day 1 predose | 217.966829001655 | 229.45218001994 | -11.4853510182846 | -7.00842650021661 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.90194444444444 | 5 | HOURS | 2017-03-27 11:54:07 | 2017-03-27 | 11:54:07 | 1 | 1 | 1 | 1 | 185 | 185 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 567 | GLOBAL | 9442FCF2-329C-4EB5-A716-82FADAE43ADC | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.93027777777778 | 5 | HOURS | 2017-03-27 11:55:49 | 2017-03-27 | 11:55:49 | 1 | 1 | 1 | 2 | 182 | 182 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 569 | GLOBAL | 85A46375-3A0F-417E-B9EC-16515E805B8B | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.96583333333333 | 5 | HOURS | 2017-03-27 11:57:57 | 2017-03-27 | 11:57:57 | 1 | 1 | 1 | 3 | 186 | 186 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 573 | GLOBAL | F9EB2C08-FBD5-4715-8260-A2130D3DC4E3 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 5 | HOURS | 1 | 1 | 1 | NA | 184.333333333333 | 184.333333333333 | ms | AVERAGE | 187.555555555556 | -3.2222222222222 | Day 1 predose | 159.3 | 164.394444444444 | -5.09444444444443 | 1.87222222222223 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.90194444444444 | 5 | HOURS | 2017-03-27 11:54:07 | 2017-03-27 | 11:54:07 | 1 | 1 | 1 | 1 | 83 | 83 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 567 | VCGMAG | 9442FCF2-329C-4EB5-A716-82FADAE43ADC | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.93027777777778 | 5 | HOURS | 2017-03-27 11:55:49 | 2017-03-27 | 11:55:49 | 1 | 1 | 1 | 2 | 86 | 86 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 569 | VCGMAG | 85A46375-3A0F-417E-B9EC-16515E805B8B | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.96583333333333 | 5 | HOURS | 2017-03-27 11:57:57 | 2017-03-27 | 11:57:57 | 1 | 1 | 1 | 3 | 82 | 82 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 573 | VCGMAG | F9EB2C08-FBD5-4715-8260-A2130D3DC4E3 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 5 | HOURS | 1 | 1 | 1 | NA | 83.6666666666667 | 83.6666666666667 | ms | AVERAGE | 78.7777777777778 | 4.8888888888889 | Day 1 predose | 85.6 | 85.3666666666667 | 0.233333333333334 | 4.65555555555557 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.90194444444444 | 5 | HOURS | 2017-03-27 11:54:07 | 2017-03-27 | 11:54:07 | 1 | 1 | 1 | 1 | 355 | 355 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 567 | VCGMAG | 9442FCF2-329C-4EB5-A716-82FADAE43ADC | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.93027777777778 | 5 | HOURS | 2017-03-27 11:55:49 | 2017-03-27 | 11:55:49 | 1 | 1 | 1 | 2 | 362 | 362 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 569 | VCGMAG | 85A46375-3A0F-417E-B9EC-16515E805B8B | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.96583333333333 | 5 | HOURS | 2017-03-27 11:57:57 | 2017-03-27 | 11:57:57 | 1 | 1 | 1 | 3 | 360 | 360 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 573 | VCGMAG | F9EB2C08-FBD5-4715-8260-A2130D3DC4E3 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 5 | HOURS | 1 | 1 | 1 | NA | 359 | 359 | ms | AVERAGE | 366.555555555556 | -7.55555555555554 | Day 1 predose | 370.966666666667 | 390.855555555556 | -19.8888888888889 | 12.3333333333334 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.90194444444444 | 5 | HOURS | 2017-03-27 11:54:07 | 2017-03-27 | 11:54:07 | 1 | 1 | 1 | 1 | 371.081058852399 | 371.081058852399 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 567 | VCGMAG | 9442FCF2-329C-4EB5-A716-82FADAE43ADC | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.93027777777778 | 5 | HOURS | 2017-03-27 11:55:49 | 2017-03-27 | 11:55:49 | 1 | 1 | 1 | 2 | 367.770059058033 | 367.770059058033 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 569 | VCGMAG | 85A46375-3A0F-417E-B9EC-16515E805B8B | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.96583333333333 | 5 | HOURS | 2017-03-27 11:57:57 | 2017-03-27 | 11:57:57 | 1 | 1 | 1 | 3 | 372.358329557047 | 372.358329557047 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 573 | VCGMAG | F9EB2C08-FBD5-4715-8260-A2130D3DC4E3 | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 5 | HOURS | 1 | 1 | 1 | NA | 370.403149155826 | 370.403149155826 | ms | AVERAGE | 380.610483970258 | -10.2073348144318 | Day 1 predose | 372.578314565288 | 387.122499004314 | -14.5441844390257 | 4.33684962459392 | Placebo group | Y | NA | VCGMAG | QTCF>=450 | N | QTCF>=500 | N | ||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.90194444444444 | 5 | HOURS | 2017-03-27 11:54:07 | 2017-03-27 | 11:54:07 | 1 | 1 | 1 | 1 | 875.545454545455 | 875.545454545455 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 567 | GLOBAL | 9442FCF2-329C-4EB5-A716-82FADAE43ADC | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.93027777777778 | 5 | HOURS | 2017-03-27 11:55:49 | 2017-03-27 | 11:55:49 | 1 | 1 | 1 | 2 | 953.666666666667 | 953.666666666667 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 569 | GLOBAL | 85A46375-3A0F-417E-B9EC-16515E805B8B | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.96583333333333 | 5 | HOURS | 2017-03-27 11:57:57 | 2017-03-27 | 11:57:57 | 1 | 1 | 1 | 3 | 903.7 | 903.7 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 573 | GLOBAL | F9EB2C08-FBD5-4715-8260-A2130D3DC4E3 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 5 | HOURS | 1 | 1 | 1 | NA | 910.970707070707 | 910.970707070707 | ms | AVERAGE | 893.921099887766 | 17.0496071829409 | Day 1 predose | 993.156592111592 | 1034.25331128748 | -41.0967191758856 | 58.1463263588265 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.90194444444444 | 5 | HOURS | 2017-03-27 11:54:07 | 2017-03-27 | 11:54:07 | 1 | 1 | 1 | 1 | 63 | 63 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 567 | VCGMAG | 9442FCF2-329C-4EB5-A716-82FADAE43ADC | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.93027777777778 | 5 | HOURS | 2017-03-27 11:55:49 | 2017-03-27 | 11:55:49 | 1 | 1 | 1 | 2 | 62 | 62 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 569 | VCGMAG | 85A46375-3A0F-417E-B9EC-16515E805B8B | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 4.96583333333333 | 5 | HOURS | 2017-03-27 11:57:57 | 2017-03-27 | 11:57:57 | 1 | 1 | 1 | 3 | 63 | 63 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 573 | VCGMAG | F9EB2C08-FBD5-4715-8260-A2130D3DC4E3 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 5 hrs | 10 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 5 | HOURS | 1 | 1 | 1 | NA | 62.6666666666667 | 62.6666666666667 | ms | AVERAGE | 60.1111111111111 | 2.55555555555555 | Day 1 predose | 69.6666666666667 | 72.5277777777778 | -2.86111111111111 | 5.41666666666666 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 5.92138888888889 | 6 | HOURS | 2017-03-27 12:55:17 | 2017-03-27 | 12:55:17 | 1 | 1 | 1 | 1 | 78 | 78 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 673 | GLOBAL | 0B967A7E-3BF9-48E1-B159-D4B48982F94C | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 5.94277777777778 | 6 | HOURS | 2017-03-27 12:56:34 | 2017-03-27 | 12:56:34 | 1 | 1 | 1 | 2 | 78 | 78 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 676 | GLOBAL | 9969271F-CF35-442C-8B5C-12744E45FAE8 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 5.95722222222222 | 6 | HOURS | 2017-03-27 12:57:26 | 2017-03-27 | 12:57:26 | 1 | 1 | 1 | 3 | 82 | 82 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 678 | GLOBAL | EF449CD6-CBB6-4185-BB8C-7DB5C39ACC02 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 6 | HOURS | 1 | 1 | 1 | NA | 79.3333333333333 | 79.3333333333333 | bpm | AVERAGE | 67.3333333333333 | 12 | Day 1 predose | 66.0333333333333 | 58.6333333333333 | 7.4 | 4.6 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 5.92138888888889 | 6 | HOURS | 2017-03-27 12:55:17 | 2017-03-27 | 12:55:17 | 1 | 1 | 1 | 1 | 189 | 189 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 673 | VCGMAG | 0B967A7E-3BF9-48E1-B159-D4B48982F94C | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 5.94277777777778 | 6 | HOURS | 2017-03-27 12:56:34 | 2017-03-27 | 12:56:34 | 1 | 1 | 1 | 2 | 189 | 189 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 676 | VCGMAG | 9969271F-CF35-442C-8B5C-12744E45FAE8 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 5.95722222222222 | 6 | HOURS | 2017-03-27 12:57:26 | 2017-03-27 | 12:57:26 | 1 | 1 | 1 | 3 | 184 | 184 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 678 | VCGMAG | EF449CD6-CBB6-4185-BB8C-7DB5C39ACC02 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 6 | HOURS | 1 | 1 | 1 | NA | 187.333333333333 | 187.333333333333 | ms | AVERAGE | 227.666666666667 | -40.3333333333333 | Day 1 predose | 196.933333333333 | 232.961111111111 | -36.0277777777778 | -4.30555555555554 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 5.92138888888889 | 6 | HOURS | 2017-03-27 12:55:17 | 2017-03-27 | 12:55:17 | 1 | 1 | 1 | 1 | 219.715849380151 | 219.715849380151 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 673 | VCGMAG | 0B967A7E-3BF9-48E1-B159-D4B48982F94C | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 5.94277777777778 | 6 | HOURS | 2017-03-27 12:56:34 | 2017-03-27 | 12:56:34 | 1 | 1 | 1 | 2 | 220.226873965764 | 220.226873965764 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 676 | VCGMAG | 9969271F-CF35-442C-8B5C-12744E45FAE8 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 5.95722222222222 | 6 | HOURS | 2017-03-27 12:57:26 | 2017-03-27 | 12:57:26 | 1 | 1 | 1 | 3 | 221.171109854921 | 221.171109854921 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 678 | VCGMAG | EF449CD6-CBB6-4185-BB8C-7DB5C39ACC02 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 6 | HOURS | 1 | 1 | 1 | NA | 220.371277733612 | 220.371277733612 | ms | AVERAGE | 243.068287022766 | -22.6970092891542 | Day 1 predose | 207.481624760022 | 229.45218001994 | -21.9705552599183 | -0.726454029235896 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 5.92138888888889 | 6 | HOURS | 2017-03-27 12:55:17 | 2017-03-27 | 12:55:17 | 1 | 1 | 1 | 1 | 179 | 179 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 673 | GLOBAL | 0B967A7E-3BF9-48E1-B159-D4B48982F94C | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 5.94277777777778 | 6 | HOURS | 2017-03-27 12:56:34 | 2017-03-27 | 12:56:34 | 1 | 1 | 1 | 2 | 180 | 180 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 676 | GLOBAL | 9969271F-CF35-442C-8B5C-12744E45FAE8 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 5.95722222222222 | 6 | HOURS | 2017-03-27 12:57:26 | 2017-03-27 | 12:57:26 | 1 | 1 | 1 | 3 | 179 | 179 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 678 | GLOBAL | EF449CD6-CBB6-4185-BB8C-7DB5C39ACC02 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 6 | HOURS | 1 | 1 | 1 | NA | 179.333333333333 | 179.333333333333 | ms | AVERAGE | 187.555555555556 | -8.2222222222222 | Day 1 predose | 157.2 | 164.394444444444 | -7.19444444444446 | -1.02777777777774 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 5.92138888888889 | 6 | HOURS | 2017-03-27 12:55:17 | 2017-03-27 | 12:55:17 | 1 | 1 | 1 | 1 | 96 | 96 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 673 | VCGMAG | 0B967A7E-3BF9-48E1-B159-D4B48982F94C | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 5.94277777777778 | 6 | HOURS | 2017-03-27 12:56:34 | 2017-03-27 | 12:56:34 | 1 | 1 | 1 | 2 | 94 | 94 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 676 | VCGMAG | 9969271F-CF35-442C-8B5C-12744E45FAE8 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 5.95722222222222 | 6 | HOURS | 2017-03-27 12:57:26 | 2017-03-27 | 12:57:26 | 1 | 1 | 1 | 3 | 93 | 93 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 678 | VCGMAG | EF449CD6-CBB6-4185-BB8C-7DB5C39ACC02 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 6 | HOURS | 1 | 1 | 1 | NA | 94.3333333333333 | 94.3333333333333 | ms | AVERAGE | 78.7777777777778 | 15.5555555555556 | Day 1 predose | 88.5 | 85.3666666666667 | 3.13333333333334 | 12.4222222222222 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 5.92138888888889 | 6 | HOURS | 2017-03-27 12:55:17 | 2017-03-27 | 12:55:17 | 1 | 1 | 1 | 1 | 359 | 359 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 673 | VCGMAG | 0B967A7E-3BF9-48E1-B159-D4B48982F94C | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 5.94277777777778 | 6 | HOURS | 2017-03-27 12:56:34 | 2017-03-27 | 12:56:34 | 1 | 1 | 1 | 2 | 363 | 363 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 676 | VCGMAG | 9969271F-CF35-442C-8B5C-12744E45FAE8 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 5.95722222222222 | 6 | HOURS | 2017-03-27 12:57:26 | 2017-03-27 | 12:57:26 | 1 | 1 | 1 | 3 | 361 | 361 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 678 | VCGMAG | EF449CD6-CBB6-4185-BB8C-7DB5C39ACC02 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 6 | HOURS | 1 | 1 | 1 | NA | 361 | 361 | ms | AVERAGE | 366.555555555556 | -5.55555555555554 | Day 1 predose | 370.5 | 390.855555555556 | -20.3555555555556 | 14.8 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 5.92138888888889 | 6 | HOURS | 2017-03-27 12:55:17 | 2017-03-27 | 12:55:17 | 1 | 1 | 1 | 1 | 391.453711655118 | 391.453711655118 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 673 | VCGMAG | 0B967A7E-3BF9-48E1-B159-D4B48982F94C | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 5.94277777777778 | 6 | HOURS | 2017-03-27 12:56:34 | 2017-03-27 | 12:56:34 | 1 | 1 | 1 | 2 | 396.344134448734 | 396.344134448734 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 676 | VCGMAG | 9969271F-CF35-442C-8B5C-12744E45FAE8 | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 5.95722222222222 | 6 | HOURS | 2017-03-27 12:57:26 | 2017-03-27 | 12:57:26 | 1 | 1 | 1 | 3 | 401.266421845848 | 401.266421845848 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 678 | VCGMAG | EF449CD6-CBB6-4185-BB8C-7DB5C39ACC02 | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 6 | HOURS | 1 | 1 | 1 | NA | 396.354755983233 | 396.354755983233 | ms | AVERAGE | 380.610483970258 | 15.7442720129753 | Day 1 predose | 381.638478340251 | 387.122499004314 | -5.484020664063 | 21.2282926770383 | Placebo group | Y | NA | VCGMAG | QTCF>=450 | N | QTCF>=500 | N | ||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 5.92138888888889 | 6 | HOURS | 2017-03-27 12:55:17 | 2017-03-27 | 12:55:17 | 1 | 1 | 1 | 1 | 771.333333333333 | 771.333333333333 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 673 | GLOBAL | 0B967A7E-3BF9-48E1-B159-D4B48982F94C | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 5.94277777777778 | 6 | HOURS | 2017-03-27 12:56:34 | 2017-03-27 | 12:56:34 | 1 | 1 | 1 | 2 | 768.25 | 768.25 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 676 | GLOBAL | 9969271F-CF35-442C-8B5C-12744E45FAE8 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 5.95722222222222 | 6 | HOURS | 2017-03-27 12:57:26 | 2017-03-27 | 12:57:26 | 1 | 1 | 1 | 3 | 728.153846153846 | 728.153846153846 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 678 | GLOBAL | EF449CD6-CBB6-4185-BB8C-7DB5C39ACC02 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 6 | HOURS | 1 | 1 | 1 | NA | 755.912393162393 | 755.912393162393 | ms | AVERAGE | 893.921099887766 | -138.008706725373 | Day 1 predose | 918.953198653199 | 1034.25331128748 | -115.300112634279 | -22.7085940910944 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 5.92138888888889 | 6 | HOURS | 2017-03-27 12:55:17 | 2017-03-27 | 12:55:17 | 1 | 1 | 1 | 1 | 74 | 74 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 673 | VCGMAG | 0B967A7E-3BF9-48E1-B159-D4B48982F94C | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 5.94277777777778 | 6 | HOURS | 2017-03-27 12:56:34 | 2017-03-27 | 12:56:34 | 1 | 1 | 1 | 2 | 80 | 80 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 676 | VCGMAG | 9969271F-CF35-442C-8B5C-12744E45FAE8 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 5.95722222222222 | 6 | HOURS | 2017-03-27 12:57:26 | 2017-03-27 | 12:57:26 | 1 | 1 | 1 | 3 | 84 | 84 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 678 | VCGMAG | EF449CD6-CBB6-4185-BB8C-7DB5C39ACC02 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 6 hrs | 11 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 6 | HOURS | 1 | 1 | 1 | NA | 79.3333333333333 | 79.3333333333333 | ms | AVERAGE | 60.1111111111111 | 19.2222222222222 | Day 1 predose | 85.0666666666667 | 72.5277777777778 | 12.5388888888889 | 6.68333333333334 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 8.40138888888889 | 8.5 | HOURS | 2017-03-27 15:24:05 | 2017-03-27 | 15:24:05 | 1 | 1 | 1 | 1 | 74 | 74 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 748 | GLOBAL | 372096C4-2B2B-4CEB-9675-B4ADCB731458 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 8.46972222222222 | 8.5 | HOURS | 2017-03-27 15:28:11 | 2017-03-27 | 15:28:11 | 1 | 1 | 1 | 2 | 73 | 73 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 752 | GLOBAL | 365A0332-D8DE-4EB7-BDAA-BABBFE7ECBED | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 8.47666666666667 | 8.5 | HOURS | 2017-03-27 15:28:36 | 2017-03-27 | 15:28:36 | 1 | 1 | 1 | 3 | 75 | 75 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 753 | GLOBAL | 6F3E3667-B88A-4B26-B769-D9E3997CCB0D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 8.5 | HOURS | 1 | 1 | 1 | NA | 74 | 74 | bpm | AVERAGE | 67.3333333333333 | 6.66666666666667 | Day 1 predose | 62 | 58.6333333333333 | 3.36666666666667 | 3.3 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 8.40138888888889 | 8.5 | HOURS | 2017-03-27 15:24:05 | 2017-03-27 | 15:24:05 | 1 | 1 | 1 | 1 | 204 | 204 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 748 | VCGMAG | 372096C4-2B2B-4CEB-9675-B4ADCB731458 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 8.46972222222222 | 8.5 | HOURS | 2017-03-27 15:28:11 | 2017-03-27 | 15:28:11 | 1 | 1 | 1 | 2 | 209 | 209 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 752 | VCGMAG | 365A0332-D8DE-4EB7-BDAA-BABBFE7ECBED | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 8.47666666666667 | 8.5 | HOURS | 2017-03-27 15:28:36 | 2017-03-27 | 15:28:36 | 1 | 1 | 1 | 3 | 205 | 205 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 753 | VCGMAG | 6F3E3667-B88A-4B26-B769-D9E3997CCB0D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 8.5 | HOURS | 1 | 1 | 1 | NA | 206 | 206 | ms | AVERAGE | 227.666666666667 | -21.6666666666667 | Day 1 predose | 213.9 | 232.961111111111 | -19.0611111111111 | -2.60555555555555 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 8.40138888888889 | 8.5 | HOURS | 2017-03-27 15:24:05 | 2017-03-27 | 15:24:05 | 1 | 1 | 1 | 1 | 229.985367595371 | 229.985367595371 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 748 | VCGMAG | 372096C4-2B2B-4CEB-9675-B4ADCB731458 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 8.46972222222222 | 8.5 | HOURS | 2017-03-27 15:28:11 | 2017-03-27 | 15:28:11 | 1 | 1 | 1 | 2 | 233.75967264168 | 233.75967264168 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 752 | VCGMAG | 365A0332-D8DE-4EB7-BDAA-BABBFE7ECBED | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 8.47666666666667 | 8.5 | HOURS | 2017-03-27 15:28:36 | 2017-03-27 | 15:28:36 | 1 | 1 | 1 | 3 | 233.734995083318 | 233.734995083318 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 753 | VCGMAG | 6F3E3667-B88A-4B26-B769-D9E3997CCB0D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 8.5 | HOURS | 1 | 1 | 1 | NA | 232.49334510679 | 232.49334510679 | ms | AVERAGE | 243.068287022766 | -10.5749419159766 | Day 1 predose | 217.370168791944 | 229.45218001994 | -12.0820112279964 | 1.50706931201981 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 8.40138888888889 | 8.5 | HOURS | 2017-03-27 15:24:05 | 2017-03-27 | 15:24:05 | 1 | 1 | 1 | 1 | 184 | 184 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 748 | GLOBAL | 372096C4-2B2B-4CEB-9675-B4ADCB731458 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 8.46972222222222 | 8.5 | HOURS | 2017-03-27 15:28:11 | 2017-03-27 | 15:28:11 | 1 | 1 | 1 | 2 | 181 | 181 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 752 | GLOBAL | 365A0332-D8DE-4EB7-BDAA-BABBFE7ECBED | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 8.47666666666667 | 8.5 | HOURS | 2017-03-27 15:28:36 | 2017-03-27 | 15:28:36 | 1 | 1 | 1 | 3 | 181 | 181 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 753 | GLOBAL | 6F3E3667-B88A-4B26-B769-D9E3997CCB0D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 8.5 | HOURS | 1 | 1 | 1 | NA | 182 | 182 | ms | AVERAGE | 187.555555555556 | -5.55555555555554 | Day 1 predose | 155.266666666667 | 164.394444444444 | -9.12777777777779 | 3.57222222222225 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 8.40138888888889 | 8.5 | HOURS | 2017-03-27 15:24:05 | 2017-03-27 | 15:24:05 | 1 | 1 | 1 | 1 | 86 | 86 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 748 | VCGMAG | 372096C4-2B2B-4CEB-9675-B4ADCB731458 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 8.46972222222222 | 8.5 | HOURS | 2017-03-27 15:28:11 | 2017-03-27 | 15:28:11 | 1 | 1 | 1 | 2 | 87 | 87 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 752 | VCGMAG | 365A0332-D8DE-4EB7-BDAA-BABBFE7ECBED | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 8.47666666666667 | 8.5 | HOURS | 2017-03-27 15:28:36 | 2017-03-27 | 15:28:36 | 1 | 1 | 1 | 3 | 88 | 88 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 753 | VCGMAG | 6F3E3667-B88A-4B26-B769-D9E3997CCB0D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 8.5 | HOURS | 1 | 1 | 1 | NA | 87 | 87 | ms | AVERAGE | 78.7777777777778 | 8.22222222222223 | Day 1 predose | 85.5 | 85.3666666666667 | 0.13333333333334 | 8.08888888888889 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 8.40138888888889 | 8.5 | HOURS | 2017-03-27 15:24:05 | 2017-03-27 | 15:24:05 | 1 | 1 | 1 | 1 | 350 | 350 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 748 | VCGMAG | 372096C4-2B2B-4CEB-9675-B4ADCB731458 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 8.46972222222222 | 8.5 | HOURS | 2017-03-27 15:28:11 | 2017-03-27 | 15:28:11 | 1 | 1 | 1 | 2 | 358 | 358 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 752 | VCGMAG | 365A0332-D8DE-4EB7-BDAA-BABBFE7ECBED | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 8.47666666666667 | 8.5 | HOURS | 2017-03-27 15:28:36 | 2017-03-27 | 15:28:36 | 1 | 1 | 1 | 3 | 356 | 356 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 753 | VCGMAG | 6F3E3667-B88A-4B26-B769-D9E3997CCB0D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 8.5 | HOURS | 1 | 1 | 1 | NA | 354.666666666667 | 354.666666666667 | ms | AVERAGE | 366.555555555556 | -11.8888888888889 | Day 1 predose | 370.766666666667 | 390.855555555556 | -20.0888888888889 | 8.20000000000005 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 8.40138888888889 | 8.5 | HOURS | 2017-03-27 15:24:05 | 2017-03-27 | 15:24:05 | 1 | 1 | 1 | 1 | 374.967263824937 | 374.967263824937 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 748 | VCGMAG | 372096C4-2B2B-4CEB-9675-B4ADCB731458 | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 8.46972222222222 | 8.5 | HOURS | 2017-03-27 15:28:11 | 2017-03-27 | 15:28:11 | 1 | 1 | 1 | 2 | 381.792554165747 | 381.792554165747 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 752 | VCGMAG | 365A0332-D8DE-4EB7-BDAA-BABBFE7ECBED | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 8.47666666666667 | 8.5 | HOURS | 2017-03-27 15:28:36 | 2017-03-27 | 15:28:36 | 1 | 1 | 1 | 3 | 383.876306821152 | 383.876306821152 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 753 | VCGMAG | 6F3E3667-B88A-4B26-B769-D9E3997CCB0D | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 8.5 | HOURS | 1 | 1 | 1 | NA | 380.212041603945 | 380.212041603945 | ms | AVERAGE | 380.610483970258 | -0.398442366312736 | Day 1 predose | 373.751759632762 | 387.122499004314 | -13.3707393715515 | 12.9722970052387 | Placebo group | Y | NA | VCGMAG | QTCF>=450 | N | QTCF>=500 | N | ||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 8.40138888888889 | 8.5 | HOURS | 2017-03-27 15:24:05 | 2017-03-27 | 15:24:05 | 1 | 1 | 1 | 1 | 813.25 | 813.25 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 748 | GLOBAL | 372096C4-2B2B-4CEB-9675-B4ADCB731458 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 8.46972222222222 | 8.5 | HOURS | 2017-03-27 15:28:11 | 2017-03-27 | 15:28:11 | 1 | 1 | 1 | 2 | 824.454545454545 | 824.454545454545 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 752 | GLOBAL | 365A0332-D8DE-4EB7-BDAA-BABBFE7ECBED | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 8.47666666666667 | 8.5 | HOURS | 2017-03-27 15:28:36 | 2017-03-27 | 15:28:36 | 1 | 1 | 1 | 3 | 797.583333333333 | 797.583333333333 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 753 | GLOBAL | 6F3E3667-B88A-4B26-B769-D9E3997CCB0D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 8.5 | HOURS | 1 | 1 | 1 | NA | 811.762626262626 | 811.762626262626 | ms | AVERAGE | 893.921099887766 | -82.1584736251405 | Day 1 predose | 980.255757575758 | 1034.25331128748 | -53.9975537117202 | -28.1609199134202 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 8.40138888888889 | 8.5 | HOURS | 2017-03-27 15:24:05 | 2017-03-27 | 15:24:05 | 1 | 1 | 1 | 1 | 60 | 60 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 748 | VCGMAG | 372096C4-2B2B-4CEB-9675-B4ADCB731458 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 8.46972222222222 | 8.5 | HOURS | 2017-03-27 15:28:11 | 2017-03-27 | 15:28:11 | 1 | 1 | 1 | 2 | 62 | 62 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 752 | VCGMAG | 365A0332-D8DE-4EB7-BDAA-BABBFE7ECBED | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 8.47666666666667 | 8.5 | HOURS | 2017-03-27 15:28:36 | 2017-03-27 | 15:28:36 | 1 | 1 | 1 | 3 | 63 | 63 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 753 | VCGMAG | 6F3E3667-B88A-4B26-B769-D9E3997CCB0D | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 8.5 hrs | 12 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 8.5 | HOURS | 1 | 1 | 1 | NA | 61.6666666666667 | 61.6666666666667 | ms | AVERAGE | 60.1111111111111 | 1.55555555555555 | Day 1 predose | 71.3666666666667 | 72.5277777777778 | -1.16111111111111 | 2.71666666666666 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 13.9486111111111 | 14 | HOURS | 2017-03-27 20:56:55 | 2017-03-27 | 20:56:55 | 1 | 1 | 1 | 1 | 73 | 73 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 825 | GLOBAL | 42E8773C-D2D1-4539-98C5-4FD01502833E | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 13.9619444444444 | 14 | HOURS | 2017-03-27 20:57:43 | 2017-03-27 | 20:57:43 | 1 | 1 | 1 | 2 | 72 | 72 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 826 | GLOBAL | 3062E4D8-0368-49DE-A87C-0C2E962F489A | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 13.9680555555556 | 14 | HOURS | 2017-03-27 20:58:05 | 2017-03-27 | 20:58:05 | 1 | 1 | 1 | 3 | 75 | 75 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 827 | GLOBAL | D5663094-4663-4EAC-9182-D59AB9BF11A4 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 14 | HOURS | 1 | 1 | 1 | NA | 73.3333333333333 | 73.3333333333333 | bpm | AVERAGE | 67.3333333333333 | 6 | Day 1 predose | 64.6333333333333 | 58.6333333333333 | 6.00000000000001 | -7.105427357601e-15 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 13.9486111111111 | 14 | HOURS | 2017-03-27 20:56:55 | 2017-03-27 | 20:56:55 | 1 | 1 | 1 | 1 | 199 | 199 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 825 | VCGMAG | 42E8773C-D2D1-4539-98C5-4FD01502833E | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 13.9619444444444 | 14 | HOURS | 2017-03-27 20:57:43 | 2017-03-27 | 20:57:43 | 1 | 1 | 1 | 2 | 201 | 201 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 826 | VCGMAG | 3062E4D8-0368-49DE-A87C-0C2E962F489A | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 13.9680555555556 | 14 | HOURS | 2017-03-27 20:58:05 | 2017-03-27 | 20:58:05 | 1 | 1 | 1 | 3 | 198 | 198 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 827 | VCGMAG | D5663094-4663-4EAC-9182-D59AB9BF11A4 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 14 | HOURS | 1 | 1 | 1 | NA | 199.333333333333 | 199.333333333333 | ms | AVERAGE | 227.666666666667 | -28.3333333333333 | Day 1 predose | 204.3 | 232.961111111111 | -28.6611111111111 | 0.327777777777783 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 13.9486111111111 | 14 | HOURS | 2017-03-27 20:56:55 | 2017-03-27 | 20:56:55 | 1 | 1 | 1 | 1 | 223.074733998063 | 223.074733998063 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 825 | VCGMAG | 42E8773C-D2D1-4539-98C5-4FD01502833E | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 13.9619444444444 | 14 | HOURS | 2017-03-27 20:57:43 | 2017-03-27 | 20:57:43 | 1 | 1 | 1 | 2 | 223.641322973708 | 223.641322973708 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 826 | VCGMAG | 3062E4D8-0368-49DE-A87C-0C2E962F489A | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 13.9680555555556 | 14 | HOURS | 2017-03-27 20:58:05 | 2017-03-27 | 20:58:05 | 1 | 1 | 1 | 3 | 224.898839525753 | 224.898839525753 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 827 | VCGMAG | D5663094-4663-4EAC-9182-D59AB9BF11A4 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 14 | HOURS | 1 | 1 | 1 | NA | 223.871632165841 | 223.871632165841 | ms | AVERAGE | 243.068287022766 | -19.1966548569249 | Day 1 predose | 212.664859238891 | 229.45218001994 | -16.7873207810487 | -2.40933407587616 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 13.9486111111111 | 14 | HOURS | 2017-03-27 20:56:55 | 2017-03-27 | 20:56:55 | 1 | 1 | 1 | 1 | 188 | 188 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 825 | GLOBAL | 42E8773C-D2D1-4539-98C5-4FD01502833E | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 13.9619444444444 | 14 | HOURS | 2017-03-27 20:57:43 | 2017-03-27 | 20:57:43 | 1 | 1 | 1 | 2 | 188 | 188 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 826 | GLOBAL | 3062E4D8-0368-49DE-A87C-0C2E962F489A | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 13.9680555555556 | 14 | HOURS | 2017-03-27 20:58:05 | 2017-03-27 | 20:58:05 | 1 | 1 | 1 | 3 | 186 | 186 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 827 | GLOBAL | D5663094-4663-4EAC-9182-D59AB9BF11A4 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 14 | HOURS | 1 | 1 | 1 | NA | 187.333333333333 | 187.333333333333 | ms | AVERAGE | 187.555555555556 | -0.2222222222222 | Day 1 predose | 156.1 | 164.394444444444 | -8.29444444444445 | 8.07222222222225 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 13.9486111111111 | 14 | HOURS | 2017-03-27 20:56:55 | 2017-03-27 | 20:56:55 | 1 | 1 | 1 | 1 | 89 | 89 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 825 | VCGMAG | 42E8773C-D2D1-4539-98C5-4FD01502833E | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 13.9619444444444 | 14 | HOURS | 2017-03-27 20:57:43 | 2017-03-27 | 20:57:43 | 1 | 1 | 1 | 2 | 89 | 89 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 826 | VCGMAG | 3062E4D8-0368-49DE-A87C-0C2E962F489A | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 13.9680555555556 | 14 | HOURS | 2017-03-27 20:58:05 | 2017-03-27 | 20:58:05 | 1 | 1 | 1 | 3 | 91 | 91 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 827 | VCGMAG | D5663094-4663-4EAC-9182-D59AB9BF11A4 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 14 | HOURS | 1 | 1 | 1 | NA | 89.6666666666667 | 89.6666666666667 | ms | AVERAGE | 78.7777777777778 | 10.8888888888889 | Day 1 predose | 86.7333333333333 | 85.3666666666667 | 1.36666666666667 | 9.52222222222223 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 13.9486111111111 | 14 | HOURS | 2017-03-27 20:56:55 | 2017-03-27 | 20:56:55 | 1 | 1 | 1 | 1 | 358 | 358 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 825 | VCGMAG | 42E8773C-D2D1-4539-98C5-4FD01502833E | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 13.9619444444444 | 14 | HOURS | 2017-03-27 20:57:43 | 2017-03-27 | 20:57:43 | 1 | 1 | 1 | 2 | 359 | 359 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 826 | VCGMAG | 3062E4D8-0368-49DE-A87C-0C2E962F489A | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 13.9680555555556 | 14 | HOURS | 2017-03-27 20:58:05 | 2017-03-27 | 20:58:05 | 1 | 1 | 1 | 3 | 359 | 359 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 827 | VCGMAG | D5663094-4663-4EAC-9182-D59AB9BF11A4 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 14 | HOURS | 1 | 1 | 1 | NA | 358.666666666667 | 358.666666666667 | ms | AVERAGE | 366.555555555556 | -7.88888888888886 | Day 1 predose | 368.1 | 390.855555555556 | -22.7555555555555 | 14.8666666666667 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 13.9486111111111 | 14 | HOURS | 2017-03-27 20:56:55 | 2017-03-27 | 20:56:55 | 1 | 1 | 1 | 1 | 382.284972421457 | 382.284972421457 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 825 | VCGMAG | 42E8773C-D2D1-4539-98C5-4FD01502833E | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 13.9619444444444 | 14 | HOURS | 2017-03-27 20:57:43 | 2017-03-27 | 20:57:43 | 1 | 1 | 1 | 2 | 381.712010516412 | 381.712010516412 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 826 | VCGMAG | 3062E4D8-0368-49DE-A87C-0C2E962F489A | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 13.9680555555556 | 14 | HOURS | 2017-03-27 20:58:05 | 2017-03-27 | 20:58:05 | 1 | 1 | 1 | 3 | 386.267986168122 | 386.267986168122 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 827 | VCGMAG | D5663094-4663-4EAC-9182-D59AB9BF11A4 | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 14 | HOURS | 1 | 1 | 1 | NA | 383.421656368664 | 383.421656368664 | ms | AVERAGE | 380.610483970258 | 2.81117239840557 | Day 1 predose | 376.454641265113 | 387.122499004314 | -10.6678577392008 | 13.4790301376063 | Placebo group | Y | NA | VCGMAG | QTCF>=450 | N | QTCF>=500 | N | ||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 13.9486111111111 | 14 | HOURS | 2017-03-27 20:56:55 | 2017-03-27 | 20:56:55 | 1 | 1 | 1 | 1 | 821.272727272727 | 821.272727272727 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 825 | GLOBAL | 42E8773C-D2D1-4539-98C5-4FD01502833E | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 13.9619444444444 | 14 | HOURS | 2017-03-27 20:57:43 | 2017-03-27 | 20:57:43 | 1 | 1 | 1 | 2 | 831.909090909091 | 831.909090909091 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 826 | GLOBAL | 3062E4D8-0368-49DE-A87C-0C2E962F489A | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 13.9680555555556 | 14 | HOURS | 2017-03-27 20:58:05 | 2017-03-27 | 20:58:05 | 1 | 1 | 1 | 3 | 802.818181818182 | 802.818181818182 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 827 | GLOBAL | D5663094-4663-4EAC-9182-D59AB9BF11A4 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 14 | HOURS | 1 | 1 | 1 | NA | 818.666666666667 | 818.666666666667 | ms | AVERAGE | 893.921099887766 | -75.2544332210998 | Day 1 predose | 937.555747215747 | 1034.25331128748 | -96.6975640717307 | 21.4431308506308 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 13.9486111111111 | 14 | HOURS | 2017-03-27 20:56:55 | 2017-03-27 | 20:56:55 | 1 | 1 | 1 | 1 | 70 | 70 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 825 | VCGMAG | 42E8773C-D2D1-4539-98C5-4FD01502833E | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 13.9619444444444 | 14 | HOURS | 2017-03-27 20:57:43 | 2017-03-27 | 20:57:43 | 1 | 1 | 1 | 2 | 69 | 69 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 826 | VCGMAG | 3062E4D8-0368-49DE-A87C-0C2E962F489A | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 13.9680555555556 | 14 | HOURS | 2017-03-27 20:58:05 | 2017-03-27 | 20:58:05 | 1 | 1 | 1 | 3 | 70 | 70 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 827 | VCGMAG | D5663094-4663-4EAC-9182-D59AB9BF11A4 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 14 hrs | 13 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 14 | HOURS | 1 | 1 | 1 | NA | 69.6666666666667 | 69.6666666666667 | ms | AVERAGE | 60.1111111111111 | 9.55555555555556 | Day 1 predose | 77.0666666666667 | 72.5277777777778 | 4.53888888888888 | 5.01666666666668 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 23.8286111111111 | 24 | HOURS | 2017-03-28 06:49:43 | 2017-03-28 | 06:49:43 | 1 | 1 | 1 | 1 | 79 | 79 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 898 | GLOBAL | 3E413739-E5C8-4325-B770-0BED4200DE27 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 23.8452777777778 | 24 | HOURS | 2017-03-28 06:50:43 | 2017-03-28 | 06:50:43 | 1 | 1 | 1 | 2 | 76 | 76 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 899 | GLOBAL | 8EE0B225-3C6F-48F0-BF3D-7B42AC8A7885 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 23.8519444444444 | 24 | HOURS | 2017-03-28 06:51:07 | 2017-03-28 | 06:51:07 | 1 | 1 | 1 | 3 | 78 | 78 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 900 | GLOBAL | DF64D258-EF5A-4165-9A0B-E8F6A74F3F61 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 24 | HOURS | 1 | 1 | 1 | NA | 77.6666666666667 | 77.6666666666667 | bpm | AVERAGE | 67.3333333333333 | 10.3333333333333 | Day 1 predose | 58.3333333333333 | 58.6333333333333 | -0.299999999999997 | 10.6333333333333 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 23.8286111111111 | 24 | HOURS | 2017-03-28 06:49:43 | 2017-03-28 | 06:49:43 | 1 | 1 | 1 | 1 | 205 | 205 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 898 | VCGMAG | 3E413739-E5C8-4325-B770-0BED4200DE27 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 23.8452777777778 | 24 | HOURS | 2017-03-28 06:50:43 | 2017-03-28 | 06:50:43 | 1 | 1 | 1 | 2 | 203 | 203 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 899 | VCGMAG | 8EE0B225-3C6F-48F0-BF3D-7B42AC8A7885 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 23.8519444444444 | 24 | HOURS | 2017-03-28 06:51:07 | 2017-03-28 | 06:51:07 | 1 | 1 | 1 | 3 | 205 | 205 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 900 | VCGMAG | DF64D258-EF5A-4165-9A0B-E8F6A74F3F61 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 24 | HOURS | 1 | 1 | 1 | NA | 204.333333333333 | 204.333333333333 | ms | AVERAGE | 227.666666666667 | -23.3333333333333 | Day 1 predose | 231.133333333333 | 232.961111111111 | -1.82777777777778 | -21.5055555555555 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 23.8286111111111 | 24 | HOURS | 2017-03-28 06:49:43 | 2017-03-28 | 06:49:43 | 1 | 1 | 1 | 1 | 239.700884761224 | 239.700884761224 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 898 | VCGMAG | 3E413739-E5C8-4325-B770-0BED4200DE27 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 23.8452777777778 | 24 | HOURS | 2017-03-28 06:50:43 | 2017-03-28 | 06:50:43 | 1 | 1 | 1 | 2 | 233.168947142979 | 233.168947142979 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 899 | VCGMAG | 8EE0B225-3C6F-48F0-BF3D-7B42AC8A7885 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 23.8519444444444 | 24 | HOURS | 2017-03-28 06:51:07 | 2017-03-28 | 06:51:07 | 1 | 1 | 1 | 3 | 237.988214215961 | 237.988214215961 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 900 | VCGMAG | DF64D258-EF5A-4165-9A0B-E8F6A74F3F61 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 24 | HOURS | 1 | 1 | 1 | NA | 236.952682040055 | 236.952682040055 | ms | AVERAGE | 243.068287022766 | -6.11560498271155 | Day 1 predose | 227.091107482438 | 229.45218001994 | -2.36107253750174 | -3.7545324452098 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 23.8286111111111 | 24 | HOURS | 2017-03-28 06:49:43 | 2017-03-28 | 06:49:43 | 1 | 1 | 1 | 1 | 186 | 186 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 898 | GLOBAL | 3E413739-E5C8-4325-B770-0BED4200DE27 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 23.8452777777778 | 24 | HOURS | 2017-03-28 06:50:43 | 2017-03-28 | 06:50:43 | 1 | 1 | 1 | 2 | 185 | 185 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 899 | GLOBAL | 8EE0B225-3C6F-48F0-BF3D-7B42AC8A7885 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 23.8519444444444 | 24 | HOURS | 2017-03-28 06:51:07 | 2017-03-28 | 06:51:07 | 1 | 1 | 1 | 3 | 188 | 188 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 900 | GLOBAL | DF64D258-EF5A-4165-9A0B-E8F6A74F3F61 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 24 | HOURS | 1 | 1 | 1 | NA | 186.333333333333 | 186.333333333333 | ms | AVERAGE | 187.555555555556 | -1.2222222222222 | Day 1 predose | 166.3 | 164.394444444444 | 1.90555555555557 | -3.12777777777777 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 23.8286111111111 | 24 | HOURS | 2017-03-28 06:49:43 | 2017-03-28 | 06:49:43 | 1 | 1 | 1 | 1 | 81 | 81 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 898 | VCGMAG | 3E413739-E5C8-4325-B770-0BED4200DE27 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 23.8452777777778 | 24 | HOURS | 2017-03-28 06:50:43 | 2017-03-28 | 06:50:43 | 1 | 1 | 1 | 2 | 86 | 86 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 899 | VCGMAG | 8EE0B225-3C6F-48F0-BF3D-7B42AC8A7885 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 23.8519444444444 | 24 | HOURS | 2017-03-28 06:51:07 | 2017-03-28 | 06:51:07 | 1 | 1 | 1 | 3 | 84 | 84 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 900 | VCGMAG | DF64D258-EF5A-4165-9A0B-E8F6A74F3F61 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 24 | HOURS | 1 | 1 | 1 | NA | 83.6666666666667 | 83.6666666666667 | ms | AVERAGE | 78.7777777777778 | 4.8888888888889 | Day 1 predose | 85.6666666666667 | 85.3666666666667 | 0.300000000000011 | 4.58888888888889 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 23.8286111111111 | 24 | HOURS | 2017-03-28 06:49:43 | 2017-03-28 | 06:49:43 | 1 | 1 | 1 | 1 | 351 | 351 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 898 | VCGMAG | 3E413739-E5C8-4325-B770-0BED4200DE27 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 23.8452777777778 | 24 | HOURS | 2017-03-28 06:50:43 | 2017-03-28 | 06:50:43 | 1 | 1 | 1 | 2 | 353 | 353 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 899 | VCGMAG | 8EE0B225-3C6F-48F0-BF3D-7B42AC8A7885 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 23.8519444444444 | 24 | HOURS | 2017-03-28 06:51:07 | 2017-03-28 | 06:51:07 | 1 | 1 | 1 | 3 | 354 | 354 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 900 | VCGMAG | DF64D258-EF5A-4165-9A0B-E8F6A74F3F61 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 24 | HOURS | 1 | 1 | 1 | NA | 352.666666666667 | 352.666666666667 | ms | AVERAGE | 366.555555555556 | -13.8888888888889 | Day 1 predose | 387.6 | 390.855555555556 | -3.25555555555553 | -10.6333333333333 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 23.8286111111111 | 24 | HOURS | 2017-03-28 06:49:43 | 2017-03-28 | 06:49:43 | 1 | 1 | 1 | 1 | 384.007026986684 | 384.007026986684 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 898 | VCGMAG | 3E413739-E5C8-4325-B770-0BED4200DE27 | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 23.8452777777778 | 24 | HOURS | 2017-03-28 06:50:43 | 2017-03-28 | 06:50:43 | 1 | 1 | 1 | 2 | 382.259116090124 | 382.259116090124 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 899 | VCGMAG | 8EE0B225-3C6F-48F0-BF3D-7B42AC8A7885 | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 23.8519444444444 | 24 | HOURS | 2017-03-28 06:51:07 | 2017-03-28 | 06:51:07 | 1 | 1 | 1 | 3 | 385.696372793617 | 385.696372793617 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 900 | VCGMAG | DF64D258-EF5A-4165-9A0B-E8F6A74F3F61 | QTCF>=450 | N | QTCF>=500 | N | ||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QTcF | QTCF | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 24 | HOURS | 1 | 1 | 1 | NA | 383.987505290142 | 383.987505290142 | ms | AVERAGE | 380.610483970258 | 3.37702131988357 | Day 1 predose | 383.454410417966 | 387.122499004314 | -3.66808858634801 | 7.04510990623157 | Placebo group | Y | NA | VCGMAG | QTCF>=450 | N | QTCF>=500 | N | ||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 23.8286111111111 | 24 | HOURS | 2017-03-28 06:49:43 | 2017-03-28 | 06:49:43 | 1 | 1 | 1 | 1 | 763.666666666667 | 763.666666666667 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 898 | GLOBAL | 3E413739-E5C8-4325-B770-0BED4200DE27 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 23.8452777777778 | 24 | HOURS | 2017-03-28 06:50:43 | 2017-03-28 | 06:50:43 | 1 | 1 | 1 | 2 | 787.5 | 787.5 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 899 | GLOBAL | 8EE0B225-3C6F-48F0-BF3D-7B42AC8A7885 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 23.8519444444444 | 24 | HOURS | 2017-03-28 06:51:07 | 2017-03-28 | 06:51:07 | 1 | 1 | 1 | 3 | 773.166666666667 | 773.166666666667 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 900 | GLOBAL | DF64D258-EF5A-4165-9A0B-E8F6A74F3F61 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | RR | RR | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 24 | HOURS | 1 | 1 | 1 | NA | 774.777777777778 | 774.777777777778 | ms | AVERAGE | 893.921099887766 | -119.143322109989 | Day 1 predose | 1035.88726190476 | 1034.25331128748 | 1.63395061728374 | -120.777272727272 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 23.8286111111111 | 24 | HOURS | 2017-03-28 06:49:43 | 2017-03-28 | 06:49:43 | 1 | 1 | 1 | 1 | 65 | 65 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 898 | VCGMAG | 3E413739-E5C8-4325-B770-0BED4200DE27 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 23.8452777777778 | 24 | HOURS | 2017-03-28 06:50:43 | 2017-03-28 | 06:50:43 | 1 | 1 | 1 | 2 | 64 | 64 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 899 | VCGMAG | 8EE0B225-3C6F-48F0-BF3D-7B42AC8A7885 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | 2017-03-27 07:00:00 | 23.8519444444444 | 24 | HOURS | 2017-03-28 06:51:07 | 2017-03-28 | 06:51:07 | 1 | 1 | 1 | 3 | 65 | 65 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 900 | VCGMAG | DF64D258-EF5A-4165-9A0B-E8F6A74F3F61 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | Tpeak-Tend | TPTE | 1 | Period 1 | Visit 1 | 1 | 24 hrs | 14 | Morning fasted dose | 2017-03-27 07:00:00 | NA | 24 | HOURS | 1 | 1 | 1 | NA | 64.6666666666667 | 64.6666666666667 | ms | AVERAGE | 60.1111111111111 | 4.55555555555556 | Day 1 predose | 70.8 | 72.5277777777778 | -1.72777777777779 | 6.28333333333335 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 27.5 hrs | 15 | Morning fasted dose | 2017-03-28 07:00:00 | 2017-03-28 07:00:00 | 3.415 | 3.5 | HOURS | 2017-03-28 10:24:54 | 2017-03-28 | 10:24:54 | 2 | 1 | 2 | 1 | 83 | 83 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 973 | GLOBAL | 82F74243-5172-45A3-BBCE-9EB0D2E09568 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 27.5 hrs | 15 | Morning fasted dose | 2017-03-28 07:00:00 | 2017-03-28 07:00:00 | 3.43555555555556 | 3.5 | HOURS | 2017-03-28 10:26:08 | 2017-03-28 | 10:26:08 | 2 | 1 | 2 | 2 | 83 | 83 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 974 | GLOBAL | C282EA2A-0084-49DF-A959-F0CADE3041B1 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 27.5 hrs | 15 | Morning fasted dose | 2017-03-28 07:00:00 | 2017-03-28 07:00:00 | 3.48027777777778 | 3.5 | HOURS | 2017-03-28 10:28:49 | 2017-03-28 | 10:28:49 | 2 | 1 | 2 | 3 | 82 | 82 | bpm | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 979 | GLOBAL | 5191DBD3-8014-474A-B1E4-96044050DDCE | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | HR | HR | 1 | Period 1 | Visit 1 | 1 | 27.5 hrs | 15 | Morning fasted dose | 2017-03-28 07:00:00 | NA | 3.5 | HOURS | 2 | 1 | 2 | NA | 82.6666666666667 | 82.6666666666667 | bpm | AVERAGE | 67.3333333333333 | 15.3333333333333 | Day 1 predose | 62.1 | 58.6333333333333 | 3.46666666666667 | 11.8666666666667 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 27.5 hrs | 15 | Morning fasted dose | 2017-03-28 07:00:00 | 2017-03-28 07:00:00 | 3.415 | 3.5 | HOURS | 2017-03-28 10:24:54 | 2017-03-28 | 10:24:54 | 2 | 1 | 2 | 1 | 178 | 178 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 973 | VCGMAG | 82F74243-5172-45A3-BBCE-9EB0D2E09568 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 27.5 hrs | 15 | Morning fasted dose | 2017-03-28 07:00:00 | 2017-03-28 07:00:00 | 3.43555555555556 | 3.5 | HOURS | 2017-03-28 10:26:08 | 2017-03-28 | 10:26:08 | 2 | 1 | 2 | 2 | 179 | 179 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 974 | VCGMAG | C282EA2A-0084-49DF-A959-F0CADE3041B1 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 27.5 hrs | 15 | Morning fasted dose | 2017-03-28 07:00:00 | 2017-03-28 07:00:00 | 3.48027777777778 | 3.5 | HOURS | 2017-03-28 10:28:49 | 2017-03-28 | 10:28:49 | 2 | 1 | 2 | 3 | 178 | 178 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 979 | VCGMAG | 5191DBD3-8014-474A-B1E4-96044050DDCE | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeak | JTP | 1 | Period 1 | Visit 1 | 1 | 27.5 hrs | 15 | Morning fasted dose | 2017-03-28 07:00:00 | NA | 3.5 | HOURS | 2 | 1 | 2 | NA | 178.333333333333 | 178.333333333333 | ms | AVERAGE | 227.666666666667 | -49.3333333333333 | Day 1 predose | 213.233333333333 | 232.961111111111 | -19.7277777777778 | -29.6055555555555 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 27.5 hrs | 15 | Morning fasted dose | 2017-03-28 07:00:00 | 2017-03-28 07:00:00 | 3.415 | 3.5 | HOURS | 2017-03-28 10:24:54 | 2017-03-28 | 10:24:54 | 2 | 1 | 2 | 1 | 215.4278005115 | 215.4278005115 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 973 | VCGMAG | 82F74243-5172-45A3-BBCE-9EB0D2E09568 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 27.5 hrs | 15 | Morning fasted dose | 2017-03-28 07:00:00 | 2017-03-28 07:00:00 | 3.43555555555556 | 3.5 | HOURS | 2017-03-28 10:26:08 | 2017-03-28 | 10:26:08 | 2 | 1 | 2 | 2 | 215.929379247718 | 215.929379247718 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 974 | VCGMAG | C282EA2A-0084-49DF-A959-F0CADE3041B1 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 27.5 hrs | 15 | Morning fasted dose | 2017-03-28 07:00:00 | 2017-03-28 07:00:00 | 3.48027777777778 | 3.5 | HOURS | 2017-03-28 10:28:49 | 2017-03-28 | 10:28:49 | 2 | 1 | 2 | 3 | 213.189325586424 | 213.189325586424 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 979 | VCGMAG | 5191DBD3-8014-474A-B1E4-96044050DDCE | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | J-Tpeakc | JTPC | 1 | Period 1 | Visit 1 | 1 | 27.5 hrs | 15 | Morning fasted dose | 2017-03-28 07:00:00 | NA | 3.5 | HOURS | 2 | 1 | 2 | NA | 214.848835115214 | 214.848835115214 | ms | AVERAGE | 243.068287022766 | -28.2194519075522 | Day 1 predose | 217.098814882779 | 229.45218001994 | -12.3533651371612 | -15.866086770391 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 27.5 hrs | 15 | Morning fasted dose | 2017-03-28 07:00:00 | 2017-03-28 07:00:00 | 3.415 | 3.5 | HOURS | 2017-03-28 10:24:54 | 2017-03-28 | 10:24:54 | 2 | 1 | 2 | 1 | 182 | 182 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 973 | GLOBAL | 82F74243-5172-45A3-BBCE-9EB0D2E09568 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 27.5 hrs | 15 | Morning fasted dose | 2017-03-28 07:00:00 | 2017-03-28 07:00:00 | 3.43555555555556 | 3.5 | HOURS | 2017-03-28 10:26:08 | 2017-03-28 | 10:26:08 | 2 | 1 | 2 | 2 | 184 | 184 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 974 | GLOBAL | C282EA2A-0084-49DF-A959-F0CADE3041B1 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 27.5 hrs | 15 | Morning fasted dose | 2017-03-28 07:00:00 | 2017-03-28 07:00:00 | 3.48027777777778 | 3.5 | HOURS | 2017-03-28 10:28:49 | 2017-03-28 | 10:28:49 | 2 | 1 | 2 | 3 | 185 | 185 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 979 | GLOBAL | 5191DBD3-8014-474A-B1E4-96044050DDCE | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | PR | PR | 1 | Period 1 | Visit 1 | 1 | 27.5 hrs | 15 | Morning fasted dose | 2017-03-28 07:00:00 | NA | 3.5 | HOURS | 2 | 1 | 2 | NA | 183.666666666667 | 183.666666666667 | ms | AVERAGE | 187.555555555556 | -3.88888888888889 | Day 1 predose | 159.433333333333 | 164.394444444444 | -4.96111111111111 | 1.07222222222222 | Placebo group | Y | NA | GLOBAL | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 27.5 hrs | 15 | Morning fasted dose | 2017-03-28 07:00:00 | 2017-03-28 07:00:00 | 3.415 | 3.5 | HOURS | 2017-03-28 10:24:54 | 2017-03-28 | 10:24:54 | 2 | 1 | 2 | 1 | 89 | 89 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 973 | VCGMAG | 82F74243-5172-45A3-BBCE-9EB0D2E09568 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 27.5 hrs | 15 | Morning fasted dose | 2017-03-28 07:00:00 | 2017-03-28 07:00:00 | 3.43555555555556 | 3.5 | HOURS | 2017-03-28 10:26:08 | 2017-03-28 | 10:26:08 | 2 | 1 | 2 | 2 | 88 | 88 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 974 | VCGMAG | C282EA2A-0084-49DF-A959-F0CADE3041B1 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 27.5 hrs | 15 | Morning fasted dose | 2017-03-28 07:00:00 | 2017-03-28 07:00:00 | 3.48027777777778 | 3.5 | HOURS | 2017-03-28 10:28:49 | 2017-03-28 | 10:28:49 | 2 | 1 | 2 | 3 | 89 | 89 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 979 | VCGMAG | 5191DBD3-8014-474A-B1E4-96044050DDCE | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QRS | QRS | 1 | Period 1 | Visit 1 | 1 | 27.5 hrs | 15 | Morning fasted dose | 2017-03-28 07:00:00 | NA | 3.5 | HOURS | 2 | 1 | 2 | NA | 88.6666666666667 | 88.6666666666667 | ms | AVERAGE | 78.7777777777778 | 9.8888888888889 | Day 1 predose | 85.0333333333333 | 85.3666666666667 | -0.333333333333329 | 10.2222222222222 | Placebo group | Y | NA | VCGMAG | N | N | ||||||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 27.5 hrs | 15 | Morning fasted dose | 2017-03-28 07:00:00 | 2017-03-28 07:00:00 | 3.415 | 3.5 | HOURS | 2017-03-28 10:24:54 | 2017-03-28 | 10:24:54 | 2 | 1 | 2 | 1 | 343 | 343 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 973 | VCGMAG | 82F74243-5172-45A3-BBCE-9EB0D2E09568 | N | N | ||||||
| SCR-004 | 1001 | Ranolazine | Ranolazine | Ranolazine | Ranolazine | QT | QT | 1 | Period 1 | Visit 1 | 1 | 27.5 hrs | 15 | Morning fasted dose | 2017-03-28 07:00:00 | 2017-03-28 07:00:00 | 3.43555555555556 | 3.5 | HOURS | 2017-03-28 10:26:08 | 2017-03-28 | 10:26:08 | 2 | 1 | 2 | 2 | 342 | 342 | ms | NA | NA | Day 1 predose | NA | NA | NA | NA | Placebo group | Y | 974 | VCGMAG | C282EA2A-0084-49DF-A959-F0CADE3041B1 | N | N |