Publications citing CiPA ECG Validation Study v1.0.0

Repeat variation and definition dependence of ECG/VCG markers: an exploratory audit of one implementation (LoopLens 10.1)
Leo Probst. Research Square, 2026. Cites: dataset

Predicting thorough QT safety profile using hERG IC10 versus IC50
Andrew G. Edwards, William Crumb. Journal of Pharmacological and Toxicological Methods, 2026. Cites: paper

Redefining cardiovascular safety: A dual-pathway, mechanistic in silico screen for the detection of trafficking-mediated and “hidden” cardiotoxicity
Mustafa Al Yagoub. Journal of Pharmacological and Toxicological Methods, 2026. Cites: paper

Improving biomarker robustness for in silico cardiac safety assessment through an excitation-contraction coupling model
Ulfa Latifa Hanum, Ali Ikhsanul Qauli, Ariyadi et al. Toxicology and Applied Pharmacology, 2026. Cites: paper

Complete atrioventricular block with prolonged QT interval
E. B. Polyakova, Е.Н. Мирошникова. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics), 2026. Cites: paper

Reassessing the Conduct of Patch Clamp Cardiac Ion Channel Assays to Improve Nonclinical Data Translation to Clinical ECG Changes and Proarrythmia Risk
Claudia P. Alvarez-Baron, Jun Wei Zhao, Donglin Guo et al. Clinical and Translational Science, 2025. Cites: paper

Drug induced TdP risks classification assay using electro-mechanical models of human ventricle based on CiPA framework
Aulia Khamas Heikhmakhtiar, Ali Ikhsanul Qauli, Yunendah Nur Fuadah et al. Toxicological Research, 2025. Cites: paper

Integrating drug effects on individual cardiac ionic currents and cardiac action potentials to understand nonclinical translation to clinical ECG changes
Lars Johannesen, Najah Abi‐Gerges, Katrina Sweat et al. Frontiers in Pharmacology, 2025. Cites: paper

CardioMark: An open-source MATLAB toolbox for ECG annotation for machine learning and academic research
Samir Abdel-Rahman, Pavel Antiperovitch, Anthony Tang et al. SoftwareX, 2025. Cites: paper

Sex-specific human electromechanical multiscale in-silico models for virtual therapy evaluation
Maxx Holmes, Zhinuo Jenny Wang, Rubén Doste et al. Journal of Molecular and Cellular Cardiology Plus, 2025. Cites: paper

Validation of new AI-based classification method for in silico cardiac safety assessment of drugs following the CiPA framework
Ulfa Latifa Hanum, Ali Ikhsanul Qauli, Yunendah Nur Fuadah et al. Archives of Toxicology, 2025. Cites: paper

Faster R-CNN approach for estimating global QRS duration in electrocardiograms with a limited quantity of annotated data
Samir Abdel-Rahman, Pavel Antiperovitch, Anthony Tang et al. Computers in Biology and Medicine, 2025. Cites: paper

Increased L-type calcium current causes action potential prolongation in Jervell and Lange-Nielsen syndrome and is a drug target
Yuko Wada, Marcia A. Blair, Teresa L. Strickland et al. medRxiv, 2025. Cites: paper

ACA-24-3995.Highlighted: Determination of lopinavir and ritonavir in hERG solution to support in vitro hERG block potency assessment using LC-MS/MS: The challenge of poor drug solubility
Sabyasachy Mistry, Jun Wei Zhao, Claudia P. Alvarez-Baron et al. Analytica Chimica Acta, 2025. Cites: paper

Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators
Paula Dominguez-Gomez, Alberto Zingaro, Laura Baldo-Canut et al. npj Digital Medicine, 2024. Cites: paper

Chloroquine: Rapidly withdrawing from first-line treatment of COVID-19
Yunlong Jia, Wenjie Tian, Yuyao Li et al. Heliyon, 2024. Cites: paper

The Current State of Realistic Heart Models for Disease Modelling and Cardiotoxicity
Kornél Kistamás, Federica Lamberto, Raminta Vaičiulevičiūtė et al. International Journal of Molecular Sciences, 2024. Cites: paper

Assessment of corrected JT-peak (JTpc) and Tpeak-to-Tend (TpTec) as proarrhythmia biomarkers in non-human primates: Outcome from a HESI consortium
Emmanuel Boulay, Simon Authier, Theresa Bartko et al. Journal of Pharmacological and Toxicological Methods, 2024. Cites: paper

An open-access database of lead-I ECG signals with practical variability scenarios
Juan Carlos Bernal-Romero, Juan Manuel Ramírez-Cortés. Proceedings - IEEE Symposium on Computer-Based Medical Systems, 2024. Cites: paper

Drug-Induced QT Prolongation
Russell Bialecki, David J. Gallacher, Jean‐Pierre Valentin. Elsevier eBooks, 2024. Cites: paper

Collaborative science in action: A 20 year perspective from the Health and Environmental Sciences Institute (HESI) Cardiac Safety Committee
Jennifer Beck Pierson, Brian R. Berridge, Ksenia Blinova et al. Journal of Pharmacological and Toxicological Methods, 2024. Cites: paper

In Silico Human Cardiomyocyte Action Potential Modeling: Exploring Ion Channel Input Combinations
Emmanuel Boulay, Éric Troncy, Vincent Jacquemet et al. International Journal of Toxicology, 2024. Cites: paper

A Survey of Cutting-edge Multimodal Sentiment Analysis
Upendra Singh, Kumar Abhishek, Hiteshwar Kumar Azad. ACM Computing Surveys, 2024. Cites: paper

Virtual clinical QT exposure-response studies – A translational computational approach
Jazmín Aguado‐Sierra, Paula Dominguez-Gomez, Ani Amar et al. Journal of Pharmacological and Toxicological Methods, 2024. Cites: paper

Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes
Kavita Raniga, Aishah Nasir, Nguyen T.N. Vo et al. Cell stem cell, 2024. Cites: paper

In Vivo Methods in Cardiovascular Safety Pharmacology
Liomar A. A. Neves, Olivera Šarenac, Michael Gralinski. Springer eBooks, 2024. Cites: paper

Overview of the ICH E14/S7B: Questions and Answers
By Jean-Pierre Valentin, Derek J. Leishman, Hugo M. Vargas. Springer eBooks, 2024. Cites: paper

Overview of the ICH E14/S7B: Questions and Answers
Jean‐Pierre Valentin, Derek J. Leishman, Hugo M. Vargas. Springer eBooks, 2024. Cites: paper

A Human-Centered AI Framework for Efficient Labelling of ECGs From Drug Safety Trials
Mously Dior Diaw, Stéphane Papelier, Alexandre Durand-Salmon et al. IEEE Transactions on Biomedical Engineering, 2023. Cites: paper

The evolving role of investigative toxicology in the pharmaceutical industry
François Pognan, Mario Beilmann, Harrie C. M. Boonen et al. Nature Reviews Drug Discovery, 2023. Cites: paper

Prevalence and Clinical Characteristics of Patients with Torsades de Pointes Complicating Acquired Atrioventricular Block
Sok‐Sithikun Bun, Nathan Heme, Florian Asarisi et al. Journal of Clinical Medicine, 2023. Cites: paper

New science, drug regulation, and emergent public health issues: The work of FDA’s division of applied regulatory science
Kimberly Chiu, Rebecca Racz, Keith Burkhart et al. Frontiers in Medicine, 2023. Cites: paper

Anti‐malarial drugs: Mechanisms underlying their proarrhythmic effects
Khalil Saadeh, Nakulan Nantha Kumar, Ibrahim T. Fazmin et al. British Journal of Pharmacology, 2022. Cites: paper

Chronic Administration of COVID-19 Drugs Fluvoxamine and Lopinavir Shortens Action Potential Duration by Inhibiting the Human Ether‐à‐go‐go–Related Gene and Cav1.2
Zequn Zheng, Dihui Cai, Yin Fu et al. Frontiers in Pharmacology, 2022. Cites: paper

Cardiovascular Diseases in the Digital Health Era: A Translational Approach from the Lab to the Clinic
A Nava, Lidia Gomez-Cid, Gonzalo Ricardo Ríos-Muñoz et al. BioTech, 2022. Cites: paper

Definition of a Sensitivity Profile for Drug Treatment and Identification on Clinical Biomarkers in Atrial Fibrillation
A Nava. 2022. Cites: paper

Pharmacological characterisation of electrocardiogram J-Tpeak interval in conscious Guinea pigs
Hisashi Nogawa, Yukiko Muraki, Tomoyuki Kawai et al. European Journal of Pharmacology, 2022. Cites: paper

Hydroxychloroquine Blood Concentrations Can Be Clinically Relevant Also After Drug Discontinuation
Simona De Gregori, Francesco Falaschi, Alessia Ballesio et al. Drugs in R&D, 2022. Cites: paper

The grapefruit polyphenol naringenin inhibits multiple cardiac ion channels
Camille Sanson, Rachid Boukaiba, Sylvie Houtmann et al. Naunyn-Schmiedeberg s Archives of Pharmacology, 2022. Cites: paper

In Vivo Methods in Cardiovascular Safety Pharmacology
Liomar A. A. Neves, Olivera Šarenac, Michael Gralinski. Springer eBooks, 2022. Cites: paper

ESC guidance for the diagnosis and management of cardiovascular disease during the COVID-19 pandemic: part 2—care pathways, treatment, and follow-up
The Task Force for the management of COVID-19 of the European Society of Cardiology, Colin Baigent, Stephan Windecker et al. Cardiovascular Research, 2021. Cites: paper

Assessment of proarrhythmogenic risk for chloroquine and hydroxychloroquine using the CiPA concept
Urs Thomet, Bogdan P. Amuzescu, Thomas Knott et al. European Journal of Pharmacology, 2021. Cites: paper

Systematic review and meta-analysis of the safety of chloroquine and hydroxychloroquine from randomized controlled trials on malarial and non-malarial conditions
Mayra Souza Botelho, Fernanda Bolfi, Renata Giacomini Occhiuto Ferreira Leite et al. Systematic Reviews, 2021. Cites: paper

Symmetric Projection Attractor Reconstruction: Sex Differences in the ECG
Jane V. Lyle, Manasi Nandi, Philip J. Aston. Frontiers in Cardiovascular Medicine, 2021. Cites: paper

ESC guidance for the diagnosis and management of cardiovascular disease during the COVID-19 pandemic: part 2—care pathways, treatment, and follow-up
The Task Force for the management of COVID-19 of the European Society of Cardiology, Colin Baigent, Stephan Windecker et al. European Heart Journal, 2021. Cites: paper

In silico approaches in organ toxicity hazard assessment: Current status and future needs for predicting heart, kidney and lung toxicities
Arianna Bassan, Vinícius M. Alves, Alexander Amberg et al. Computational Toxicology, 2021. Cites: paper

Cardiac Ion Channel Inhibition
Cinzia Bordoni, Daniel J. Brough, Gemma Davison et al. Royal Society of Chemistry eBooks, 2021. Cites: paper

Current evidence for the risk of PR prolongation, QRS widening, QT prolongation, from lopinavir, ritonavir, atazanavir, and saquinavir
Denio Adrianus Ridjab, Ignatius Ivan, Fanny Budiman et al. Medicine, 2021. Cites: paper

Electrophysiological and ECG Effects of Perhexiline, a Mixed Cardiac Ion Channel Inhibitor, Evaluated in Nonclinical Assays and in Healthy Subjects
Mark G. Midei, Börje Darpö, Greg Ayers et al. The Journal of Clinical Pharmacology, 2021. Cites: paper

Differentiating multichannel block on the guinea pig ECG: Use of Tpeak-Tend and J-Tpeak
Matthew R Skinner, Ed Hale, Peter Ceuppens et al. Journal of Pharmacological and Toxicological Methods, 2021. Cites: paper

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