Publications citing CiPA ECG Validation Study v1.0.0

Concentration‐QT modelling of the novel DHFR inhibitor P218 in healthy male volunteers
Jörg Täubel, Ulrike Lorch, Georg Ferber et al. British Journal of Clinical Pharmacology, 2021. Cites: paper

In silico Exploration of Interactions Between Potential COVID-19 Antiviral Treatments and the Pore of the hERG Potassium Channel—A Drug Antitarget
Ehab Al‐Moubarak, Mohsen Sharifi, Jules C. Hancox. Frontiers in Cardiovascular Medicine, 2021. Cites: paper

The New S7B/E14 Question and Answer Draft Guidance for Industry: Contents and Commentary
Börje Darpö, Georg Ferber. The Journal of Clinical Pharmacology, 2021. Cites: paper

Effects of Chloroquine and Hydroxychloroquine on the Cardiovascular System - Limitations for Use in the Treatment of COVID-19
Stephani Correia Brazão, Lis Jappour Autran, Rosane de Oliveira Lopes et al. International Journal of Cardiovascular Sciences, 2021. Cites: paper

A powerful test for the maximum treatment effect in thorough QT/QTc studies
Yuhao Deng, Fangyi Chen, Yang Li et al. Statistics in Medicine, 2021. Cites: paper

Choosing the Appropriate QRS Detector
Justus Eilers, Jonas Chromik, Bert Arnrich A. International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC), 2021. Cites: paper

Cracking the Chloroquine Conundrum: The Application of Defective UiO-66 Metal–Organic Framework Materials to Prevent the Onset of Heart Defects—In Vivo and In Vitro
Przemysław Jakub Jodłowski, Grzegorz Kurowski, Łukasz Kuterasiński et al. ACS Applied Materials & Interfaces, 2020. Cites: paper

Development of a Physiologically-Based Pharmacokinetic (PBPK) Model of Nebulized Hydroxychloroquine for Pulmonary Delivery to COVID-19 Patients
Nasir Idkaidek, Feras Ibrahim Hawari, Yasmeen Dodin et al. Drug Research, 2020. Cites: paper

Off-label use of chloroquine, hydroxychloroquine, azithromycin and lopinavir/ritonavir in COVID-19 risks prolonging the QT interval by targeting the hERG channel
Zequn Zheng, Yujia Wu, Dingding Qian et al. European Journal of Pharmacology, 2020. Cites: paper

Translational Models and Tools to Reduce Clinical Trials and Improve Regulatory Decision Making for QTc and Proarrhythmia Risk (ICH E14/S7B Updates)
David G. Strauss, Wendy Wu, Zhihua Li et al. Clinical Pharmacology & Therapeutics, 2020. Cites: paper

Systems and Clinical Pharmacology of COVID-19 Therapeutic Candidates: A Clinical and Translational Medicine Perspective
Simone Perazzolo, Linxi Zhu, Weixian Lin et al. Journal of Pharmaceutical Sciences, 2020. Cites: paper

A Modified Heart Dipole Model for the Generation of Pathological ECG Signals
Mario Versaci, Giovanni Angiulli, Fabio La Foresta. Computation, 2020. Cites: paper

Cardiotoxicity induced by the combination therapy of chloroquine and azithromycin in human embryonic stem cell-derived cardiomyocytes
Ye Seul Kim, Soo Yong Lee, Jung Won Yoon et al. BMB Reports, 2020. Cites: paper

Spontaneous reported cardiotoxicity induced by lopinavir/ritonavir in COVID-19. An alleged past-resolved problem
Audrey Fresse, Delphine Viard, Serena Romani et al. International Journal of Cardiology, 2020. Cites: paper

Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives
Xiaolei Zhang, Zhuo-ming Li, Jiantao Ye et al. Acta Pharmacologica Sinica, 2020. Cites: paper

Identification of Drug-Induced Multichannel Block and Proarrhythmic Risk in Humans Using Continuous T Vector Velocity Effect Profiles Derived From Surface Electrocardiograms
Werner Bystricky, Christoph Maier, Gary A. Gintant et al. Frontiers in Physiology, 2020. Cites: paper

Systematic Review and Meta-analysis of the Safety of Chloroquine and Hydroxychloroquine From Randomized Controlled Trials on Malarial and Non-malarial Conditions
Mayra Souza Botelho, Fernanda Bolfi, Renata Giacomini Occhiuto Ferreira Leite et al. Research Square, 2020. Cites: paper

Assessment of Cardiotoxicity With Stem Cell-based Strategies
Aaltje Maria Stella Stoter, Marc N. Hirt, Justus Stenzig et al. Clinical Therapeutics, 2020. Cites: paper

How to overcome cardiovascular challenges in COVID-19 patients: a guide for common practice.
Pegah Eslami, Mohammadreza Tabary, Arash Dooghaie Moghadam et al. Acta bio-medica dell'Ateneo parmense/Acta biomedica, 2020. Cites: paper

COVID-19 prevention and treatment: A critical analysis of chloroquine and hydroxychloroquine clinical pharmacology
Nicholas John White, James A Watson, Richard M. Hoglund et al. PLoS Medicine, 2020. Cites: paper

Physiologically‐Based Pharmacokinetic Modeling to Predict the Clinical Efficacy of the Coadministration of Lopinavir and Ritonavir against SARS‐CoV‐2
Aarzoo Thakur, Shawn Pei Feng Tan, James Chun Yip Chan. Clinical Pharmacology & Therapeutics, 2020. Cites: paper

HRS/EHRA/APHRS/LAHRS/ACC/AHA Worldwide Practice Update for Telehealth and Arrhythmia Monitoring During and After a Pandemic
Niraj Varma, Nassir F. Marrouche, Luis Aguinaga et al. Circulation Arrhythmia and Electrophysiology, 2020. Cites: paper

Pharmacokinetics and Pharmacological Properties of Chloroquine and Hydroxychloroquine in the Context of COVID‐19 Infection
Melanie R. Nicol, Abhay Joshi, Matthew L. Rizk et al. Clinical Pharmacology & Therapeutics, 2020. Cites: paper

QT Interval Prolongation Under Hydroxychloroquine/Azithromycin Association for Inpatients With SARS‐CoV‐2 Lower Respiratory Tract Infection
Sok‐Sithikun Bun, Philippe Taghji, Johan Courjon et al. Clinical Pharmacology & Therapeutics, 2020. Cites: paper

HRS/EHRA/APHRS/LAHRS/ACC/AHA worldwide practice update for telehealth and arrhythmia monitoring during and after a pandemic
Niraj Varma, Nassir F. Marrouche, Luis Aguinaga et al. Journal of Arrhythmia, 2020. Cites: paper

Cardiac effects and toxicity of chloroquine: a short update
Kanigula Mubagwa. International Journal of Antimicrobial Agents, 2020. Cites: paper

HRS/EHRA/APHRS/LAHRS/ACC/AHA worldwide practice update for telehealth and arrhythmia monitoring during and after a pandemic
Niraj Varma, Nassir F. Marrouche, Luis Aguinaga et al. Heart Rhythm, 2020. Cites: paper

HRS/EHRA/APHRS/LAHRS/ACC/AHA Worldwide Practice Update for Telehealth and Arrhythmia Monitoring During and After a Pandemic
Niraj Varma, Nassir F. Marrouche, Luis Aguinaga et al. Journal of the American College of Cardiology, 2020. Cites: paper

HRS/EHRA/APHRS/LAHRS/ACC/AHA worldwide practice update for telehealth and arrhythmia monitoring during and after a pandemic
Niraj Varma, Nassir F. Marrouche, Luis Aguinaga et al. EP Europace, 2020. Cites: paper

Chloroquine or Hydroxychloroquine for COVID‐19: Is Cardiotoxicity a Concern?
Timothy J. Kamp, Mohamed H. Hamdan, Craig T. January. Journal of the American Heart Association, 2020. Cites: paper

Connecting Hydroxychloroquine In Vitro Antiviral Activity to In Vivo Concentration for Prediction of Antiviral Effect: A Critical Step in Treating Patients With Coronavirus Disease 2019
Jianghong Fan, Xinyuan Zhang, Jiang Liu et al. Clinical Infectious Diseases, 2020. Cites: paper

RETRACTED: Chloroquine or hydroxychloroquine for COVID-19: why might they be hazardous?
Christian Funck‐Brentano, Joe‐Elie Salem. The Lancet, 2020. Cites: paper

Response to the editorial “COVID-19 in patients with cardiovascular diseases”
Christian Funck‐Brentano, Joe‐Elie Salem, Lee S. Nguyen et al. Archives of cardiovascular diseases, 2020. Cites: paper

Heart Rate Correction of the J-to-Tpeak Interval
Katerina Hnatkova, José Vicente, Lars Johannesen et al. Scientific Reports, 2019. Cites: paper

Novel method for action potential measurements from intact cardiac monolayers with multiwell microelectrode array technology
Heather Brant Hayes, Anthony M. Nicolini, Colin A. Arrowood et al. Scientific Reports, 2019. Cites: paper

Evaluation of the Effect of 5 QT‐Positive Drugs on the JTpeak Interval — An Analysis of ECGs From the IQ‐CSRC Study
Börje Darpö, Charles Benson, Randy Brown et al. The Journal of Clinical Pharmacology, 2019. Cites: paper

Electrophysiological characterization of drug response in hSC-derived cardiomyocytes using voltage-sensitive optical platforms
Emily R. Pfeiffer, Godfrey L. Smith, Beibei Cai et al. Journal of Pharmacological and Toxicological Methods, 2019. Cites: paper

T vector velocity: A new ECG biomarker for identifying drug effects on cardiac ventricular repolarization
Werner Bystricky, Christoph Maier, Gary A. Gintant et al. PLoS ONE, 2019. Cites: paper

HiPSC-CMs from different sex and ethnic origin donors exhibit qualitatively different responses to several classes of pharmacological challenges
Haoyu Zeng, Jixin Wang, Holly Clouse et al. Journal of Pharmacological and Toxicological Methods, 2019. Cites: paper

Novel High-Throughput Quantitation of Potent hERG Blocker Dofetilide in Human Plasma by Liquid Chromatography Tandem Mass Spectrometry: Application in a Phase 1 ECG Biomarker Validation Study
Murali Krishna Matta, Suresh Narayanasamy, José Vicente et al. Journal of Analytical Toxicology, 2019. Cites: paper

Introduction toin silicomodel for proarrhythmic risk assessment under the CiPA initiative
Jin-Sol Park, Ji‐Young Jeon, Jiho Yang et al. Translational and Clinical Pharmacology, 2019. Cites: paper

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