Database Open Access
I-CARE: International Cardiac Arrest REsearch consortium Database
Edilberto Amorim , Wei-Long Zheng , Jong Woo Lee , Susan Herman , Mohammad Ghassemi , Adithya Sivaraju , Nicolas Gaspard , Jeannette Hofmeijer , Michel J A M van Putten , Matthew Reyna , Gari Clifford , Brandon Westover
Published: June 16, 2023. Version: 2.0
I-CARE is now available on Google Cloud (June 22, 2023, 1:23 p.m.)
When using this resource, please cite:
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Amorim, E., Zheng, W., Lee, J. W., Herman, S., Ghassemi, M., Sivaraju, A., Gaspard, N., Hofmeijer, J., van Putten, M. J. A. M., Reyna, M., Clifford, G., & Westover, B. (2023). I-CARE: International Cardiac Arrest REsearch consortium Database (version 2.0). PhysioNet. https://doi.org/10.13026/avek-0p97.
Please include the standard citation for PhysioNet:
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Goldberger, A., Amaral, L., Glass, L., Hausdorff, J., Ivanov, P. C., Mark, R., ... & Stanley, H. E. (2000). PhysioBank, PhysioToolkit, and PhysioNet: Components of a new research resource for complex physiologic signals. Circulation [Online]. 101 (23), pp. e215–e220.
The International Cardiac Arrest REsearch consortium (I-CARE) Database includes baseline clinical information and continuous electroencephalogram (EEG) and electrocardiogram (ECG) recordings from comatose patients following cardiac arrest. The patients were admitted to an intensive care unit (ICU) in one of seven academic hospitals in the U.S. and Europe and monitored for several hours to several days. The long-term neurological function of the patients was determined using the Cerebral Performance Category scale.
More than 6 million cardiac arrests happen every year worldwide, with survival rates ranging from 1% to 10% depending on geographic location . Severe brain injury is the main determinant of poor outcome for patients surviving cardiac arrest resuscitation [1,2]. Most patients surviving to ICU admission will be comatose, and 50% to 80% will have life-sustaining therapies withdrawn due to a perceived poor neurological prognosis .
Brain monitoring with EEG aims to reduce the subjectivity in neurologic prognostication following cardiac arrest [4-9]. Clinical neurophysiologists have identified numerous patterns of brain activity that help to predict prognosis following cardiac arrest, including the presences of reduced voltage, burst suppression (alternating periods of high and low voltage), seizures, and a variety of seizure-like patterns . The evolution of EEG patterns over time may provide additional predictive information [6,7]. However, qualitative interpretation of continuous EEG is laborious, expensive, and requires review from neurologists with advanced training in neurophysiology who are unavailable in most medical centers.
Automated analysis of continuous EEG and other data has the potential to improve prognostic accuracy and to increase access to brain monitoring where experts are not readily available [6,7]. However, the datasets used in most studies typically only have small numbers of patients (<100) from single hospitals, which are unsuitable for deployment of several types of machine learning methods for EEG data analysis. To overcome this limitation the International Cardiac Arrest REsearch consortium (I-CARE) assembled a large collection of clinical, EEG, and ECG data with neurologic outcomes from comatose patients following cardiac arrest. The I-CARE dataset includes seven hospitals from the United States and Europe.
The database originates from seven academic hospitals in the U.S. and Europe led by investigators part of the International Cardiac Arrest REsearch consortium (I-CARE).
- Rijnstate Hospital, Arnhem, The Netherlands (Jeannette Hofmeijer).
- Medisch Spectrum Twente, Enschede, The Netherlands (Barry J. Ruijter, Marleen C. Tjepkema-Cloostermans, Michel J. A. M. van Putten).
- Erasme Hospital, Brussels, Belgium (Nicolas Gaspard).
- Massachusetts General Hospital, Boston, Massachusetts, USA (Edilberto Amorim, Wei-Long Zheng, Mohammad Ghassemi, and M. Brandon Westover).
- Brigham and Women’s Hospital, Boston, Massachusetts, USA (Jong Woo Lee).
- Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA (Susan T. Herman).
- Yale New Haven Hospital, New Haven, Connecticut, USA (Adithya Sivaraju).
This database consists of clinical, EEG, and ECG data from adult patients with out-of-hospital or in-hospital cardiac arrest who had return of heart function (i.e., return of spontaneous circulation [ROSC]) but remained comatose - defined as the inability to follow verbal commands and a Glasgow Coma Score inferior or equal to 8.
The initial database release contains data for over 32,712 hours of data in 80,809 recording segments from 607 patients - this is the public training set for the George B. Moody PhysioNet Challenge 2023. This database release does not contain data from the remaining 413 patients that we are retaining as the hidden validation and test sets for the Challenge.
All patients were admitted to an ICU and had their brain activity monitored with continuous EEG. Monitoring was typically started within hours of cardiac arrest and continued for several hours to several days depending on the patient's condition, so the recording start time and duration varies from patient to patient. This database includes EEG data and, when possible, ECG data for each patient. This project contains the part of the database that we have shared as a public training set for the PhysioNet Challenge 2023; the remainder of the database has been retained as private validation and test sets for the Challenge. Data from one hospital system were omitted from the training and validation sets to assess generalizability to unseen data.
Patient information recorded at the time of admission (age, sex, and a hospital identifier), location of arrest (out or in-hospital), type of cardiac rhythm recorded at the time of resuscitation (shockable rhythms include ventricular fibrillation or ventricular tachycardia and non-shockable rhythms include asystole and pulseless electrical activity), and the time between cardiac arrest and ROSC. Patient temperature after cardiac arrest is controlled using a closed-loop feedback device (TTM) in most patients unless there are contraindications such as severe and difficult to control hypotension or delay in hospital admission. For patients undergoing TTM, the temperature level can be controlled at either 36 or 33 degrees Celsius.
Neurological Prognostication and Outcome Assessment
All participating hospitals have protocols for multimodal neurological prognostication that follow international guideline recommendations. Formal neurological prognostication is deferred until the normothermia phase and confounding from sedatives can be minimized.
Clinical outcome was determined prospectively in two centers by phone interview (at 6 months from ROSC), and at the remaining five hospitals retrospectively through chart review (at 3-6 months from ROSC). Neurological function was determined using the best Cerebral Performance Category (CPC) scale . CPC is an ordinal scale ranging from 1 to 5, ranging from good neurological function to death.
Clinical and EEG data were de-identified. Patients with age above 89 years old are listed with age "90". EEG timestamps are organized based on the time elapsed since ROSC. The hospital identifiers do not identify the hospital name.
All EEG signal data are provided in WFDB format, with the signal data are stored in MATLAB MAT files (MAT v4 format). For example, the binary signal file
0284_001_004_EEG.mat contains the first segment of the EEG signal data, starting at 4 hours, 7 minutes, and 23 seconds after cardiac arrest and ending at 4 hours, 59 minutes, and 59 seconds after cardiac arrest, for patient 0284 of the I-CARE patient cohort. The plain text header file
0284_001_004_EEG.hea describes the contents of this signal file as well as the start time, stop time, and utility frequency (i.e., powerline frequency or mains frequency) for the data.
When possible, the channel names have been standardized between and within different hospitals. Different channels are available for different hospitals and different patients, including those from the same hospital. Even when a channel has been provided, it may be disconnected or noisy. The channels are organized into an EEG group, an ECG group, a reference (REF) group, and an other (OTHER) group:
- EEG: Fp1, Fp2, F7, F8, F3, F4, T3, T4, C3, C4, T5, T6, P3, P4, O1, O2, Fz, Cz, Pz, Fpz, Oz, F9
- ECG: ECG, ECG1, ECG2, ECGL, ECGR
- REF: RAT1, RAT2, REF, C2, A1, A2, BIP1, BIP2, BIP3, BIP4, Cb2, M1, M2, In1-Ref2, In1-Ref3
- OTHER: SpO2, EMG1, EMG2, EMG3, LAT1, LAT2, LOC, ROC, LEG1, LEG2
The recordings were segmented so that each segment ends at the hour, or the end of the recording, whichever occurs first. Noisy recordings with artifacts were intentionally preserved .
Clinical Data and Patient Outcome
The following clinical data is contained in each .txt file:
Age (in years): Number
Sex: Male, Female
Hospital: A, B, C, D, E, F
ROSC (return of spontaneous circulation, in minutes): Time from cardiac arrest to return of spontaneous circulation
OHCA (out-of-hospital cardiac arrest): True = out of hospital cardiac arrest, False = in-hospital cardiac arrest
Shockable Rhythm: True = shockable rhythm, False = non-shockable rhythm
TTM (targeted temperature management; in Celsius): 33, 36, or NaN for no TTM
Outcome: Good (CPC score of 1-2), Poor (CPC score of 3-5)
CPC: Cerebral Performance Category (CPC) score (ordinal scale 1-5)
- CPC = 1: good neurological function and independent for activities of daily living
- CPC = 2: moderate neurological disability but independent for activities of daily living
- CPC = 3: severe neurological disability
- CPC = 4: unresponsive wakefulness syndrome [previously known as vegetative state]
- CPC = 5: dead.
We have grouped CPC scores in two categories:
- “Good outcome”: CPC = 1 or 2
- “Poor outcome”: CPC = 3, 4, or 5
These data are in a WFDB-compatible format, and WFDB packages can be used to read them.
We have implemented example prediction algorithms in MATLAB and Python that read the data:
- MATLAB example at .
- Python example at .
By downloading the data, you agree not to repost the data or to publish or otherwise share any work that uses the data, in full or in part, before the end of the PhysioNet Challenge 2023 except to the Computing in Cardiology conference.
Data collection and analysis was performed under independent Institutional Review Board approvals at participating hospitals, and a data sharing agreement was made among participating hospitals. This was a retrospective analysis of data obtained as part of the usual care and the requirement for informed consent was waived.
This study was supported by the American Heart Association (20CDA35310297), CURE Epilepsy Foundation (Taking Flight Award), Neurocritical Care Society (NCS research training fellowship), Weil-Society of Critical Care Medicine Research Grant, the NIH (1K23NS090900, 1R01NS102190, 1R01NS102574, 1R01NS107291, 1K23NS119794, R01EB030362), Epilepsiefonds (NEF 14-18), and Dutch Heart Foundation (2018T070).
Conflicts of Interest
M.V.P. is founder of Clinical Science Systems. Clinical Science Systems did not contribute funding nor played any role in the study. M.B.W. is a co-founder of Beacon Biosignals. Beacon Biosignals neither contributed funding nor played any role in the study.
- Yan, S., Gan, Y., Jiang, N. et al. The global survival rate among adult out-of-hospital cardiac arrest patients who received cardiopulmonary resuscitation: a systematic review and meta-analysis. Crit Care 24, 61 (2020). https://doi.org/10.1186/s13054-020-2773-2.
- Dankiewicz J, Cronberg T, Lilja G, et al. Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest. N Engl J Med. 2021;384:2283–2294.
- Elmer J, Torres C, Aufderheide TP, Austin MA, Callaway CW, Golan E, Herren H, Jasti J, Kudenchuk PJ, Scales DC, Stub D, Richardson DK, Zive DM; Resuscitation Outcomes Consortium. Association of early withdrawal of life-sustaining therapy for perceived neurological prognosis with mortality after cardiac arrest. Resuscitation. 2016 May;102:127-35. doi: 10.1016/j.resuscitation.2016.01.016. Epub 2016 Feb 3. PMID: 26836944; PMCID: PMC4834233.
- Amorim E, Rittenberger JC, Zheng JJ, et al. Continuous EEG monitoring enhances multimodal outcome prediction in hypoxic-ischemic brain injury. Resuscitation. 2016;109:121–126.
- Hofmeijer J, Beernink TMJ, Bosch FH, Beishuizen A, Tjepkema-Cloostermans MC, van Putten MJAM. Early EEG contributes to multimodal outcome prediction of postanoxic coma. Neurology. 2015;85:137–143.
- Zheng W-L, Amorim E, Jing J, et al. Predicting neurological outcome in comatose patients after cardiac arrest with multiscale deep neural networks. Resuscitation. 2021;169:86–94.
- Zheng W-L, Amorim E, Jing J, et al. Predicting Neurological Outcome from Electroencephalogram Dynamics in Comatose Patients after Cardiac Arrest with Deep Learning. IEEE Trans Biomed Eng. Epub 2021.:1–1.
- Khazanova D, Douglas VC, Amorim E. A matter of timing: EEG monitoring for neurological prognostication after cardiac arrest in the era of targeted temperature management. Minerva Anestesiol. 2021;87:704–713.
- Ruijter BJ, van Putten MJAM, van den Bergh WM, Tromp SC, Hofmeijer J. Propofol does not affect the reliability of early EEG for outcome prediction of comatose patients after cardiac arrest. Clin Neurophysiol Off J Int Fed Clin Neurophysiol. 2019;130:1263–1270.
- Taccone FS, Horn J, Storm C, et al. Death after awakening from post-anoxic coma: the “Best CPC” project. Crit Care Lond Engl. 2019;23:107.
- International Cardiac Arrest EEG Consortium (ICARE) Dataset with Deep Learning. https://github.com/bdsp-core/icare-dl.
- PhysioNet 2023 Challenge MATLAB Example. https://github.com/physionetchallenges/matlab-example-2023
- PhysioNet 2023 Challenge Python Example. https://github.com/physionetchallenges/python-example-2023
Anyone can access the files, as long as they conform to the terms of the specified license.
Total uncompressed size: 1.5 TB.
Access the files
- Access the files using the Google Cloud Storage Browser here. Login with a Google account is required.
Access the data using the Google Cloud command line tools (please refer to the gsutil
documentation for guidance):
gsutil -m -u YOUR_PROJECT_ID cp -r gs://i-care-2.0.physionet.org DESTINATION
Download the files using your terminal:
wget -r -N -c -np https://physionet.org/files/i-care/2.0/